Ordering Recommendation
Acceptable panel to detect the two most common inherited thrombophilias (prothrombin related and factor V Leiden related).
Mnemonic
Methodology
Polymerase Chain Reaction/Fluorescence Monitoring
Performed
Sun-Sat
Reported
2-6 days
New York DOH Approval Status
Specimen Required
Lavender (EDTA), pink (K2 EDTA) or yellow (ACD Solution A or B).
Transport 4 mL whole blood. (Min: 3 mL)
Refrigerated.
Plasma or serum; collection of specimen in sodium heparin tubes. Frozen specimens in glass collection tubes.
Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month.
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
0097720 | Factor V Leiden (F5) R506Q Mutation | Negative: This sample is negative for factor V Leiden, R506Q mutation. |
0055655 | Methylenetetrahydrofolate Reductase (MTHFR) 2 Variants | Negative: Neither of the MTHFR variants tested, c.665C>T (previously designated C677T) and c.1286A>C (previously designated A1298C), were detected. Other causes of elevated homocysteine levels were not evaluated. |
0056060 | Prothrombin (F2) c.*97G>A (G20210A) Pathogenic Variant | |
Interpretive Data
Refer to report
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
81240; 81241; 81291
Components
Component Test Code* | Component Chart Name | LOINC |
---|
Aliases
- FVL R506Q, MTHFR, and Factor II mutation panel
- Hypercoag
- Hypercoagulable Panel