Ordering Recommendation

Acceptable panel to detect the two most common inherited thrombophilias (prothrombin related and factor V Leiden related).

Mnemonic
THROMDNA
Methodology

Polymerase Chain Reaction/Fluorescence Monitoring

Performed

Sun-Sat

Reported

2-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA), pink (K2 EDTA) or yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or serum; collection of specimen in sodium heparin tubes.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month.

Reference Interval
Test Number
Components
Reference Interval
0097720 Factor V Leiden (F5) R506Q Mutation Negative: This sample is negative for factor V Leiden, R506Q mutation.
0055655 Methylenetetrahydrofolate Reductase (MTHFR) 2 Variants Negative: Neither of the MTHFR variants tested, c.665C>T (previously designated C677T) and c.1286A>C (previously designated A1298C), were detected. Other causes of elevated homocysteine levels were not evaluated.
0056060 Prothrombin (F2) c.*97G>A (G20210A) Pathogenic Variant

Interpretive Data

Refer to report

No compliance statements are in use for this test.

Note
Hotline History
N/A
CPT Codes

81240; 81241; 81291

Components
Component Test Code* Component Chart Name LOINC
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • FVL R506Q, MTHFR, and Factor II mutation panel
  • Hypercoag
  • Hypercoagulable Panel
Thrombotic Risk, DNA Panel