Ordering Recommendation

Support the diagnosis of immune neutropenia in various autoimmune disorders.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Plain red or serum separator tube.

Specimen Preparation

Remove serum from cells ASAP or within 2 hours of collection.  Transfer 3 mL serum to an ARUP Standard Transport Tube and freeze. (Min: 0.5 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month


Qualitative Flow Cytometry


Mon, Thu


1-5 days

Reference Interval


Interpretive Data

Neutrophil-associated antibodies may cause neutropenia in various autoimmune disorders including Felty syndrome, SLE and drug-induced neutropenia.  Febrile transfusion reactions and isoimmune neonatal neutropenia may also be caused by antibodies to neutrophil-specific antigens or HLA antigens.

A positive result on this test is not definitive for specific antineutrophil antibodies, since anti-HLA antibodies and immune complexes may also cause a positive result. The results of this test should be correlated to clinical history and other data.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Circulating antibodies in patient's serum are measured by flow cytometry after incubation with normal neutrophils. Values greater than 2 standard deviations of a normal control population are interpreted as "weakly positive" and greater than 3 standard deviations as "positive".

This test should not be confused with Anti-Neutrophil Cytoplasmic Antibody, IgG (0050811 - ANCA).

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0055506 Neutrophil Associated Antibodies 41617-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Anti-Granulocyte Antibodies
  • Anti-Leukocyte Ab
  • Anti-Neutrophil Antibodies
  • Granulocyte Ab
  • NAIg
  • Neutrophil Antibody
Neutrophil-Associated Antibodies