Ordering Recommendation
Highly specific serologic test that aids in the workup of suspected rheumatoid arthritis or undifferentiated inflammatory arthritides. Rheumatoid Arthritis Panel (3004055) is the preferred test.
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Refrigerated.
Urine or plasma. Contaminated, hemolyzed, grossly icteric, heat-inactivated, or severely lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
19 Units or less | Negative |
20-39 Units | Weak positive |
40-59 Units | Moderate positive |
60 Units or Greater | Strong positive |
Interpretive Data
Anti-cyclic citrullinated peptide (anti-CCP), IgG antibodies are present in about 69-83 percent of patients with rheumatoid arthritis (RA) and have specificities of 93-95 percent. These autoantibodies may be present in the preclinical phase of disease, are associated with future RA development, and may predict radiographic joint destruction. Patients with weak positive results should be monitored and testing repeated.
FDA
Note
Hotline History
CPT Codes
86200
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0055256 | Cyclic Citrullinated Peptide Ab, IgG | 33935-8 |
Aliases
- ACPA Antibody
- Anti Citrullinated Antibody
- Anti Citrulline
- Anti-CCP
- Anti-CCP Antibody
- Anti-Citrullinated Ab
- Anti-Citrullinated Antibody
- Anti-Citrullinated Protein/Peptide Antibody (ACPA)
- Anti-Citrulline Antibody
- Anti-Cyclic Citrullinated Peptide
- AntiCCP Antibody
- Anticitrullinated Antibody
- Anticitrullinated Protein/Peptide Antibody (ACPA)
- Anticitrulline Antibody
- Anticyclic Citrullinated Peptide (CCP) Antibody
- CCP
- CCP3 Antibody
- Citrullinated Ab
- Citrullinated Antibody
- Citrullinated Protein/Peptide Antibody (ACPA)
- Citrulline Antibody
- Soft-CCP