Ordering Recommendation

Highly specific serologic test that aids in the workup of suspected rheumatoid arthritis or undifferentiated inflammatory arthritides.  Rheumatoid Arthritis Panel (2003277) is preferred test.

Mnemonic
CCP IGG
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Urine or plasma. Contaminated, hemolyzed, grossly icteric, heat-inactivated, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
19 Units or less Negative
20-39 Units Weak positive
40-59 Units Moderate positive
60 Units or Greater Strong positive

Interpretive Data

Anti-cyclic citrullinated peptide (anti-CCP), IgG antibodies are present in about 69-83 percent of patients with rheumatoid arthritis (RA) and have specificities of 93-95 percent. These autoantibodies may be present in the preclinical phase of disease, are associated with future RA development, and may predict radiographic joint destruction. Patients with weak positive results should be monitored and testing repeated.

No compliance statements are in use for this test.

Note
Hotline History
N/A
CPT Codes

86200

Components
Component Test Code* Component Chart Name LOINC
0055256 Cyclic Citrullinated Peptide Ab, IgG 33935-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ACPA Antibody
  • Anti Citrullinated Antibody
  • Anti Citrulline
  • Anti-CCP
  • Anti-CCP Antibody
  • Anti-Citrullinated Ab
  • Anti-Citrullinated Antibody
  • Anti-Citrullinated Protein/Peptide Antibody (ACPA)
  • Anti-Citrulline Antibody
  • Anti-Cyclic Citrullinated Peptide
  • AntiCCP Antibody
  • Anticitrullinated Antibody
  • Anticitrullinated Protein/Peptide Antibody (ACPA)
  • Anticitrulline Antibody
  • Anticyclic Citrullinated Peptide (CCP) Antibody
  • CCP
  • CCP3 Antibody
  • Citrullinated Ab
  • Citrullinated Antibody
  • Citrullinated Protein/Peptide Antibody (ACPA)
  • Citrulline Antibody
  • Soft-CCP
Cyclic Citrullinated Peptide (CCP) Antibody, IgG