Liver-Kidney Microsome - 1 Antibody, IgG

0055241
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Example Reports
Negative
Positive

Ordering Recommendation

Differential evaluation of autoimmune liver disease of unknown etiology, especially autoimmune hepatitis (AIH) of childhood onset. Use in combination with Liver Cytosolic Antigen Type 1 (LC-1) Antibody, IgG (2010711) when evaluating for AIH-2.

Mnemonic

LKM1 IGG

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun, Tue, Thu

Reported

1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

0.0-20.0 U Negative
20.1-24.9 U Equivocal
25.0 U or greater Positive

Interpretive Data

A positive result indicates the presence of IgG antibodies to recombinant human P450 2D6 and suggests the possibility of autoimmune hepatitis, type 2. A negative LKM-1 does not rule out the presence of autoimmune hepatitis, type 2.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86376

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Components

Component Test Code* Component Chart Name LOINC
0055241 Liver-Kid Microsome-1 Ab, IgG by ELISA 47318-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Liver-Kidney Microsome -1 antibody, IgG ELISA
  • Liver-Kidney Microsome -Type 1 antibody, IgG ELISA
  • LKM-1 IgG ELISA
  • LKM-Type 1 IgG ELISA
Liver-Kidney Microsome - 1 Antibody, IgG