Ordering Recommendation
Differential evaluation of autoimmune liver disease of unknown etiology, especially autoimmune hepatitis (AIH) of childhood onset. Use in combination with Liver Cytosolic Antigen Type 1 (LC-1) Antibody, IgG (2010711) when evaluating for AIH-2.
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun, Tue, Thu
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
0.0-20.0 U | Negative |
20.1-24.9 U | Equivocal |
25.0 U or greater | Positive |
Interpretive Data
A positive result indicates the presence of IgG antibodies to recombinant human P450 2D6 and suggests the possibility of autoimmune hepatitis, type 2. A negative LKM-1 does not rule out the presence of autoimmune hepatitis, type 2.
FDA
Note
Hotline History
CPT Codes
86376
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0055241 | Liver-Kid Microsome-1 Ab, IgG by ELISA | 47318-1 |
Aliases
- Liver-Kidney Microsome -1 antibody, IgG ELISA
- Liver-Kidney Microsome -Type 1 antibody, IgG ELISA
- LKM-1 IgG ELISA
- LKM-Type 1 IgG ELISA