Ordering Recommendation

Recommended for the evaluation of autoimmune liver disease or hepatitis of unknown etiology.

Mnemonic
SLA
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun, Tue, Thu

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
0.0-20.0 U Negative
20.1-24.9 U Equivocal
Greater than or equal to 25.0 U Positive

Interpretive Data

The presence of SLA antibodies has almost 100% specificity for autoimmune hepatitis, although only 12-30% have these antibodies.  Thus, a negative SLA IgG test does not rule out autoimmune hepatitis.

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

83516

Components
Component Test Code* Component Chart Name LOINC
0055235 Soluble Liver Antigen Antibody, IgG 38420-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-SLA-LP
  • Anti-SLA/LP
Soluble Liver Antigen Antibody, IgG