Ordering Recommendation
Aid in evaluation and management of multiple myeloma and related plasma cell disorders. Indicated for the diagnosis of patients with oligosecretory or nonsecretory multiple myeloma and light chain amyloidosis.
Mnemonic
Methodology
Quantitative Immunoturbidimetry
Performed
Sun-Sat
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Plasma. Grossly Hemolyzed and Lipemic Samples
After separation from cells: Ambient: Unacceptable; Refrigerated: 3 weeks; Frozen: 6 months
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
Lambda Qnt Free Light Chains | 5.71-26.30 mg/L | |
Kappa Qnt Free Light Chains | 3.30 - 19.40 mg/L | |
Kappa/Lambda Free Light Chain Ratio | 0.26-1.65 |
Interpretive Data
Undetected antigen excess is a rare event but cannot be excluded. Free light chain results should always be interpreted in conjunction with other clinical and laboratory findings.
FDA
Note
This assay is highly sensitive to increasing concentrations of monoclonal free kappa or free lambda light chains in the serum of patients with evolving or relapsing myelomas.
Hotline History
Hotline History
CPT Codes
83521 x2
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0055168 | Kappa Qnt Free Light Chains | 36916-5 |
0055169 | Lambda Qnt Free Light Chains | 33944-0 |
0055179 | Kappa/Lambda Free Light Chain Ratio | 80517-6 |
Aliases
- Kappa Qnt Free Light Chains
- Kappa/Lambda Free Light Chain Ratio
- Lambda Qnt Free Light Chains