Ordering Recommendation

Generally not recommended for the diagnosis of acute disease/encephalitis. May aid in diagnosing varicella-zoster virus vasculopathy.

Mnemonic
VZECSF
Methodology

Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun - Sat

Reported

Within 24 hours

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or xanthochromic specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Effective February 18, 2020

134.9 IV or less Negative - No significant level of IgG antibody to varicella-zoster virus detected.
135.0-164.9 IV Equivocal - Repeat testing in 10-14 days may be helpful.
165.0 IV or greater Positive - IgG antibody to varicella-zoster virus detected, which may indicate a current or past varicella-zoster infection.

Interpretive Data

The detection of antibodies to varicella-zoster in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
CPT Codes

86787

Components
Component Test Code* Component Chart Name LOINC
0054444 VZV Antibody IgG CSF 58755-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CSF VZV
  • Herpes Zoster Antibodies CSF
  • Varicella-Zoster Antibody CSF
  • Varicella-zoster IgG CSF
  • VZ AB IgG CSF
  • VZ Ab, CSF
Varicella-Zoster Virus Antibody, IgG, CSF