Ordering Recommendation
Generally not recommended for the diagnosis of acute disease/encephalitis. May aid in diagnosing varicella-zoster virus vasculopathy.
Mnemonic
Methodology
Semi-Quantitative Chemiluminescent Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
Specimen Required
CSF.
Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Refrigerated. Also acceptable: Frozen.
Contaminated, heat-inactivated, hemolyzed, or xanthochromic specimens.
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval
Effective February 18, 2020
134.9 IV or less | Negative - No significant level of IgG antibody to varicella-zoster virus detected. |
135.0-164.9 IV | Equivocal - Repeat testing in 10-14 days may be helpful. |
165.0 IV or greater | Positive - IgG antibody to varicella-zoster virus detected, which may indicate a current or past varicella-zoster infection. |
Interpretive Data
The detection of antibodies to varicella-zoster in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Modified FDA
Note
Hotline History
CPT Codes
86787
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0054444 | VZV Antibody IgG CSF | 58755-0 |
Aliases
- CSF VZV
- Herpes Zoster Antibodies CSF
- Varicella-Zoster Antibody CSF
- Varicella-zoster IgG CSF
- VZ AB IgG CSF
- VZ Ab, CSF