Ordering Recommendation

Generally not recommended for the diagnosis of acute disease/encephalitis. May aid in diagnosing varicella-zoster virus vasculopathy.

Mnemonic
VZECSF
Methodology

Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun - Sat

Reported

Within 24 hours

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or xanthochromic specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Effective February 18, 2020

134.9 IV or less Negative - No significant level of IgG antibody to varicella-zoster virus detected.
135.0-164.9 IV Equivocal - Repeat testing in 10-14 days may be helpful.
165.0 IV or greater Positive - IgG antibody to varicella-zoster virus detected, which may indicate a current or past varicella-zoster infection.

Interpretive Data

The detection of antibodies to varicella-zoster in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.

Compliance Category

Modified FDA

Note
Hotline History
N/A
CPT Codes

86787

Components
Component Test Code* Component Chart Name LOINC
0054444 VZV Antibody IgG CSF 58755-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CSF VZV
  • Herpes Zoster Antibodies CSF
  • Varicella-Zoster Antibody CSF
  • Varicella-zoster IgG CSF
  • VZ AB IgG CSF
  • VZ Ab, CSF
Varicella-Zoster Virus Antibody, IgG, CSF