Ordering Recommendation

Aid in the diagnosis of measles encephalitis. False-positive results will occur due to low incidence of measles in the U.S.

Mnemonic
MEASLMCSF
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Mon-Fri

Reported

1-5 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions

Specimen types other than CSF. Contaminated, heat-inactivated, or hemolyzed specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
0.79 AU or less Negative - No significant level of IgM antibodies to measles (rubeola) virus detected.
0.80-1.20 AU Equivocal - Repeat testing in 10-14 days may be helpful.
1.21 AU or greater Positive - IgM antibodies to measles (rubeola) virus detected. Suggestive of current or recent infection or immunization.  However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection or immunization.

Interpretive Data

The detection of antibodies to rubeola in CSF may indicate central nervous system infection.  However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

86765

Components
Component Test Code* Component Chart Name LOINC
0054441 Measles, Rubeola, Antibody IgM CSF 13283-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • English Measles
  • measles IgM CSF
  • MMR
  • Rubeola IgM CSF
Measles (Rubeola) Antibody, IgM, CSF