Ordering Recommendation

Aid in the diagnosis of measles encephalitis. False positive results are possible and it is recommended that testing only be performed in individuals with known exposure.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 0.5 mL CSF to an ARUP standard transport tube. (Min: 0.2 mL)
New York State Clients: 1 mL (Min: 0.075 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.
New York State Clients: Refrigerated

Unacceptable Conditions

Bacterially contaminated, heat-inactivated, hemolyzed, or xanthochromic specimens.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
New York State Clients: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 month

Methodology

Semi-Quantitative Indirect Fluorescent Antibody (IFA)

Performed

Mon-Fri

Reported

1-5 days

Reference Interval

Test Number
Components
Reference Interval
  Measles, Rubeola, Antibody IgM CSF Less than 1:2

Interpretive Data

The detection of antibodies to rubeola in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.


Less than 1:2 Negative: No evidence of recent infection. False-negative results are possible if the specimen was collected too soon after exposure.
1:2 or greater Positive: Indicative of recent primary measles infection.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

86765

Components

Component Test Code* Component Chart Name LOINC
0054441 Measles, Rubeola, Antibody IgM CSF 21502-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • English Measles
  • measles IgM CSF
  • MMR
  • Rubeola IgM CSF
Measles (Rubeola) Antibody, IgM, CSF by IFA