Cytomegalovirus by Quantitative PCR

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Example Reports
Detected
Not Detected
Ordering Recommendation

Detect and quantify cytomegalovirus (CMV).

Mnemonic
CMV QNT
Methodology

Quantitative Polymerase Chain Reaction

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA) or pink (K2EDTA), or Bronchoalveolar lavage (BAL).

Specimen Preparation

Separate plasma from cells. Transfer 1 mL plasma, or whole blood, or BAL to a sterile container. (Min: 0.5 mL).

Storage/Transport Temperature

Whole blood: Refrigerated. All others: Frozen.

Unacceptable Conditions

Heparinized specimens.

Remarks

Specimen source required.

Stability

Plasma: Ambient: 24 hours; Refrigerated: 5 days; Frozen: 1 year 
Whole blood: Ambient: 7 days; Refrigerated: 7 days; Frozen: 7 days
BAL: Ambient: 24 hours; Refrigerated: 5 days; Frozen: 3 months

Reference Interval

Not detected

Interpretive Data

The quantitative range of this test is 2.6- 6.6 log copies/mL (390-3,900,000 copies/mL) or 2.4- 6.4 log IU/mL (227- 2,270,000 IU/mL). One IU/mL of CMV DNA is approximately 1.72 copies/mL.

A negative result (less than 2.6 log copies/mL [less than 390 copies/mL] OR less than 2.4 log IU/mL [less than 227 IU/mL]) does not rule out the presence of PCR inhibitors in the patient specimen or CMV DNA concentrations below the level of detection of the test. Inhibition may also lead to underestimation of viral quantitation.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Note

The limit of quantification for this DNA test is 2.6 log copies/mL (390 copies/mL) or 2.4 log IU/mL (227 IU/mL). If the test DID NOT DETECT the virus, the test result will be reported as "<2.6 log copies/mL (<390 copies/mL)" and "<2.4 log IU/mL (<227 IU/mL)."  If the test DETECTED the presence of the virus but was not able to accurately quantify the number of copies, the test result will be reported as "Not Quantified."

Hotline History
N/A
CPT Codes

87497

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Components
Component Test Code* Component Chart Name LOINC
0051814 Cytomegalovirus Quant by PCR, Interp 40444-2
0051815 Cytomegalovirus Quant by PCR, Log Cpy/mL 54206-8
2002316 Cytomegalovirus Quant by PCR, Cpy/mL 30247-1
2006534 Cytomegalovirus Quant by PCR, IU/mL 72493-0
2006535 Cytomegalovirus Quant by PCR, Log IU/mL 72494-8
2012051 Cytomegalovirus Quant by PCR, Source 31208-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CMV Quant PCR
  • CMV quantitative
  • herpes
  • HHV-5
  • Human herpesvirus 5
  • Viral load monitoring
Cytomegalovirus by Quantitative PCR