Ordering Recommendation

Initial screening for suspected deficiency in the lectin complement pathway.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum separator tube or plain red.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min 0.2 mL)

Storage/Transport Temperature

Frozen.  Also acceptable: Refrigerated if maintained at temperature for less than 7 days.

Unacceptable Conditions

Nonserum, contaminated, or heat-inactivated specimens.


After separation from cells: Ambient: 48 hours; Refrigerated: 7 days; Frozen: 30 days (avoid repeated freeze/thaw cycles)


Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)




1-8 days

Reference Interval

Greater than or equal to 76 ng/mL

Interpretive Data

Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis and hepatitis B and in autoimmune disorders, including recurrent spontaneous abortion and systemic lupus erythematosis.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0051695 Mannose Binding Lectin 30152-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Mannan Binding Lectin
  • Mannose-Binding Lectin, S MBL
Mannose Binding Lectin