Mannose Binding Lectin
Initial screening for suspected deficiency in the lectin complement pathway.
Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
New York DOH Approval Status
Serum separator tube or plain red.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min 0.2 mL)
Frozen. Also acceptable: Refrigerated if maintained at temperature for less than 7 days.
Nonserum, contaminated, or heat-inactivated specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 7 days; Frozen: 30 days (avoid repeated freeze/thaw cycles)
Greater than or equal to 76 ng/mL
Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis and hepatitis B and in autoimmune disorders, including recurrent spontaneous abortion and systemic lupus erythematosis.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0051695||Mannose Binding Lectin||30152-3|
- Mannan Binding Lectin
- Mannose-Binding Lectin, S MBL