Initial screening for suspected deficiency in the lectin complement pathway.
Quantitative Enzyme-Linked Immunosorbent Assay
New York DOH Approval Status
Serum separator tube, plain red, or green (lithium heparin).
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min 0.2 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Specimens collected in EDTA or citrate. Contaminated or heat-inactivated specimens.
After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Greater than 50 ng/mL
Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis and hepatitis B and in autoimmune disorders, including recurrent spontaneous abortion and systemic lupus erythematosis.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0051695||Mannose Binding Lectin||30152-3|
- Mannan Binding Lectin
- Mannose-Binding Lectin, S