Ordering Recommendation
Acceptable single screening test for celiac disease. Screen includes tTG antibodies IgA and IgG, and DGP antibodies IgA and IgG. Celiac Disease Reflexive Cascade (2008114) or Tissue Transglutaminase (tTG) Antibody, IgA (0097709) is the preferred test for screening patients with suspected celiac disease.
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon, Wed, Fri
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Refrigerated.
Plasma or other body fluids. Contaminated, heat-inactivated, hemolyzed, icteric, or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval
19 Units or less | Negative - No significant level of detectable IgA or IgG antibodies against human tissue transglutaminase or gliadin peptide. |
20 Units or greater | Positive - Presence of IgA and/or IgG antibodies against human tissue transglutaminase and/or gliadin peptide; suggests possibility of certain gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis. |
Interpretive Data
FDA
Note
This test is a combined antibody screen for tissue transglutaminase and deamidated gliadin-derived peptide antibodies, IgA and IgG.
Hotline History
CPT Codes
83516
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0051691 | Celiac Disease Dual Antigen Screen | 63420-4 |
Aliases
- Celiac Sprue
- Combined tissue Transglutaminase (tTG) and deamidated (DGP) IgG and IgA
- combined tTG and DGP IgG and IGA