Ordering Recommendation

Acceptable single screening test for celiac disease. Screen includes tTG antibodies IgA and IgG, and DGP antibodies IgA and IgG. Celiac Disease Reflexive Cascade (2008114) or Tissue Transglutaminase (tTG) Antibody, IgA (0097709) is the preferred test for screening patients with suspected celiac disease.

Mnemonic
TTG DGP
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Mon, Wed,  Fri

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or other body fluids. Contaminated, heat-inactivated, hemolyzed, icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
19 Units or less Negative - No significant level of detectable IgA or IgG antibodies against human tissue transglutaminase or gliadin peptide.
20 Units or greater Positive - Presence of IgA and/or IgA antibodies against human tissue transglutaminase and/or gliadin peptide; suggests possibility of certain gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis.

Interpretive Data



No compliance statements are in use for this test.

Note

This test is a combined antibody screen for tissue transglutaminase and deamidated gliadin-derived peptide antibodies, IgA and IgG.

Hotline History
N/A
CPT Codes

83516

Components
Component Test Code* Component Chart Name LOINC
0051691 Celiac Disease Dual Antigen Screen 63420-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Celiac Sprue
  • Combined tissue Transglutaminase (tTG) and deamidated (DGP) IgG and IgA
  • combined tTG and DGP IgG and IGA
Celiac Disease Dual Antigen Screen