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0051668
Connective Tissue Diseases Profile
CONN
Ordering Recommendation
Confirmatory test for more common systemic autoimmune rheumatic diseases (ie, connective tissue diseases).
New York DOH Approval Status
This test is New York state approved.
Specimen Required
Patient Preparation
Collect
Serum separator tube.
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Plasma or other body fluids. Bacterially contaminated specimens.
Remarks
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Multiplex Bead Assay
Performed
Sun-Sat
Reported
1-3 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Smith (ENA) Antibody, IgG | 40 AU/mL or less | |
| Smith/RNP (ENA) Ab, IgG | 19 Units or less | |
| SSA-52 (Ro52) (ENA) Antibody, IgG | 40 AU/mL or less | |
| SSA-60 (Ro60) (ENA) Antibody, IgG | 40 AU/mL or less | |
| SSB (La) (ENA) Antibody, IgG | 40 AU/mL or less | |
| Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG | 40 AU/mL or less | |
| Ribosome P Antibody, IgG | 0-40 AU/mL | |
| Centromere Ab, IgG | 0-40 AU/mL | |
| Scleroderma (Scl-70) (ENA) Antibody, IgG | 40 AU/mL or less |
Interpretive Data
Refer to report.
| Component | Interpretation | |
|---|---|---|
| Smith (ENA) Antibody, IgG | 29 AU/mL or less 30-40 AU/mL 41 AU/mL or greater |
Negative Equivocal Positive |
| Smith/RNP (ENA) Antibody, IgG | 19 Units or less 20-39 Units 40-80 Units 81 Units or greater |
Negative Weak Positive Moderate Positive Strong Positive |
| SSA-52 (Ro52) (ENA) Antibody, IgG | 29 AU/mL or Less 30-40 AU/mL 41 AU/mL or greater |
Negative Equivocal Positive |
| SSA-60 (Ro60) (ENA) Antibody, IgG | 29 AU/mL or Less 30-40 AU/mL 41 AU/mL or greater |
Negative Equivocal Positive |
| SSB (La) (ENA) Antibody, IgG | 29 AU/mL or less 30-40 AU/mL 41 AU/mL or greater |
Negative Equivocal Positive |
| Jo-1 Antibody, IgG | 29 AU/mL or less 30-40 AU/mL 41 AU/mL or greater |
Negative Equivocal Positive |
| Ribosomal P Protein Antibody | 29 AU/mL or less 30-40 AU/mL 41 AU/mL or greater |
Negative Equivocal Positive |
| Centromere Antibody, IgG | 29 AU/mL or less 30-40 AU/mL 41 AU/mL or greater |
Negative Equivocal Positive |
| Scleroderma (Scl-70) (ENA) Antibody, IgG | 29 AU/mL or less 30-40 AU/mL 41 AU/mL or greater |
Negative Equivocal Positive |
Compliance Category
FDA
Note
Hotline History
N/A
CPT Codes
86235 x7; 83516 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050085 | Smith (ENA) Antibody, IgG | 18323-6 |
| 0050470 | Smith/RNP (ENA) Ab, IgG | 33983-8 |
| 0050599 | Scleroderma (Scl-70) (ENA) Antibody, IgG | 47322-3 |
| 0050691 | SSA-52 (Ro52) (ENA) Antibody, IgG | 31625-7 |
| 0050692 | SSB (La) (ENA) Antibody, IgG | 29965-1 |
| 0050714 | Centromere Ab, IgG | 29966-9 |
| 0099249 | Ribosome P Antibody, IgG | 13636-6 |
| 0099592 | Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG | 33571-1 |
| 2012055 | SSA-60 (Ro60) (ENA) Antibody, IgG | 53019-6 |
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
- Anti-SSA
- Anti-SSB
- Smith (ENA) Antibody, IgG
- Antibodies to Extractable Nuclear Antigens
- Autoantibodies to Scl 70 Antigen
- Ribonucleoprotein Autoantibodies
- Ro Ab
- Scl 70 Antibodies
- Scleroderma Antibodies
- Smith Antigen
- SSB (La) (ENA) Antibody, IgG
- SSB LA
- Smith Autoantibodies
- SmRNP Autoantibodies
- SSA (Ro) (ENA) Antibody, IgG
- SSA Ro
- Anti-Sm IgG
- Scleroderma (Scl-70) (ENA) Antibody, IgG
- Anti-RNP
- Anti-ENA
- Sm/RNP (ENA) Antibody, IgG
Connective Tissue Diseases Profile
