Connective Tissue Diseases Profile

0051668
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Negative
Positive

Ordering Recommendation

Confirmatory test for more common systemic autoimmune rheumatic diseases (ie, connective tissue diseases).

Mnemonic

CONN

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or other body fluids. Bacterially contaminated specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Effective May 18, 2015

Test Number
 Components
 Reference Interval
0050085 Smith (ENA) Antibody, IgG
29 AU/mL or less Negative
30-40 AU/mL Equivocal
41 AU/mL or greater Positive

0050470 Smith/RNP (ENA) Antibody, IgG
19 Units or less Negative
20-39 Units Weak Positive
40-80 Units Moderate Positive
81 Units or greater Strong Positive

2012074 SSA 52 and 60 (Ro) (ENA) Antibodies, IgG
Test Number
 Components
 Reference Interval
SSA-52 (Ro52) (ENA) Antibody, IgG 29 AU/mL or Less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
SSA-60 (Ro60) (ENA) Antibody, IgG 29 AU/mL or Less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive

0050692 SSB (La) (ENA) Antibody, IgG
29 AU/mL or less Negative
30-40 AU/mL Equivocal
41 AU/mL or greater Positive

0099592 Jo-1 Antibody, IgG
29 AU/mL or less Negative
30-40 AU/mL Equivocal
41 AU/mL or greater Positive

0099249 Ribosomal P Protein Antibody
29 AU/mL or less Negative
30-40 AU/mL Equivocal
41 AU/mL or greater Positive

0050714 Centromere Antibody, IgG
29 AU/mL or less Negative
30-40 AU/mL Equivocal
41 AU/mL or greater Positive

0050599 Scleroderma (Scl-70) (ENA) Antibody, IgG
29 AU/mL or less Negative
30-40 AU/mL Equivocal
41 AU/mL or greater Positive

Interpretive Data

Refer to report.

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
09/07/2021
X
X
X
N/A

CPT Codes

86235 x7; 83516 x2

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Components

Component Test Code* Component Chart Name LOINC
0050085 Smith (ENA) Antibody, IgG 18323-6
0050470 Smith/RNP (ENA) Ab, IgG 33983-8
0050599 Scleroderma (Scl-70) (ENA) Antibody, IgG 47322-3
0050691 SSA-52 (Ro52) (ENA) Antibody, IgG 31625-7
0050692 SSB (La) (ENA) Antibody, IgG 29965-1
0050714 Centromere Ab, IgG 29966-9
0099249 Ribosome P Antibody, IgG 13636-6
0099592 Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG 33571-1
2012055 SSA-60 (Ro60) (ENA) Antibody, IgG 53019-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-ENA
  • Anti-RNP
  • Anti-Sm IgG
  • Anti-SSA
  • Anti-SSB
  • Antibodies to Extractable Nuclear Antigens
  • Autoantibodies to Scl 70 Antigen
  • Ribonucleoprotein Autoantibodies
  • Ro Ab
  • Scl 70 Antibodies
  • Scleroderma (Scl-70) (ENA) Antibody, IgG
  • Scleroderma Antibodies
  • Sm/RNP (ENA) Antibody, IgG
  • Smith (ENA) Antibody, IgG
  • Smith Antigen
  • Smith Autoantibodies
  • SmRNP Autoantibodies
  • SSA (Ro) (ENA) Antibody, IgG
  • SSA Ro
  • SSB (La) (ENA) Antibody, IgG
  • SSB LA
Connective Tissue Diseases Profile