Connective Tissue Diseases Profile

0051668
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Negative
Positive

Ordering Recommendation

Confirmatory test for more common systemic autoimmune rheumatic diseases (ie, connective tissue diseases).

Mnemonic

CONN

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or other body fluids. Bacterially contaminated specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month

Reference Interval

Test Number
 Components
 Reference Interval
  Smith (ENA) Antibody, IgG 40 AU/mL or less
  Smith/RNP (ENA) Ab, IgG 19 Units or less
  SSA-52 (Ro52) (ENA) Antibody, IgG 40 AU/mL or less
  SSA-60 (Ro60) (ENA) Antibody, IgG 40 AU/mL or less
  SSB (La) (ENA) Antibody, IgG 40 AU/mL or less
  Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG 40 AU/mL or less
  Ribosome P Antibody, IgG 0-40 AU/mL
  Centromere Ab, IgG 0-40 AU/mL
  Scleroderma (Scl-70) (ENA) Antibody, IgG 40 AU/mL or less

Interpretive Data

Refer to report.


Component Interpretation
Smith (ENA) Antibody, IgG 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
Smith/RNP (ENA) Antibody, IgG 19 Units or less
20-39 Units
40-80 Units
81 Units or greater		 Negative
Weak Positive
Moderate Positive
Strong Positive
SSA-52 (Ro52) (ENA) Antibody, IgG 29 AU/mL or Less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
SSA-60 (Ro60) (ENA) Antibody, IgG 29 AU/mL or Less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
SSB (La) (ENA) Antibody, IgG 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
Jo-1 Antibody, IgG 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
Ribosomal P Protein Antibody 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
Centromere Antibody, IgG 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
Scleroderma (Scl-70) (ENA) Antibody, IgG 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/22/2022
X
09/07/2021
X
X
X
N/A

CPT Codes

86235 x7; 83516 x2

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Components

Component Test Code* Component Chart Name LOINC
0050085 Smith (ENA) Antibody, IgG 18323-6
0050470 Smith/RNP (ENA) Ab, IgG 33983-8
0050599 Scleroderma (Scl-70) (ENA) Antibody, IgG 47322-3
0050691 SSA-52 (Ro52) (ENA) Antibody, IgG 31625-7
0050692 SSB (La) (ENA) Antibody, IgG 29965-1
0050714 Centromere Ab, IgG 29966-9
0099249 Ribosome P Antibody, IgG 13636-6
0099592 Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG 33571-1
2012055 SSA-60 (Ro60) (ENA) Antibody, IgG 53019-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-ENA
  • Anti-RNP
  • Anti-Sm IgG
  • Anti-SSA
  • Anti-SSB
  • Antibodies to Extractable Nuclear Antigens
  • Autoantibodies to Scl 70 Antigen
  • Ribonucleoprotein Autoantibodies
  • Ro Ab
  • Scl 70 Antibodies
  • Scleroderma (Scl-70) (ENA) Antibody, IgG
  • Scleroderma Antibodies
  • Sm/RNP (ENA) Antibody, IgG
  • Smith (ENA) Antibody, IgG
  • Smith Antigen
  • Smith Autoantibodies
  • SmRNP Autoantibodies
  • SSA (Ro) (ENA) Antibody, IgG
  • SSA Ro
  • SSB (La) (ENA) Antibody, IgG
  • SSB LA
Connective Tissue Diseases Profile