0051668
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Connective Tissue Diseases Profile

CONN
Example Reports
Negative
Positive

Ordering Recommendation

Confirmatory test for more common systemic autoimmune rheumatic diseases (ie, connective tissue diseases).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or other body fluids. Bacterially contaminated specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-3 days

Reference Interval

Test Number
 Components
 Reference Interval
  Smith (ENA) Antibody, IgG 40 AU/mL or less
  Smith/RNP (ENA) Ab, IgG 19 Units or less
  SSA-52 (Ro52) (ENA) Antibody, IgG 40 AU/mL or less
  SSA-60 (Ro60) (ENA) Antibody, IgG 40 AU/mL or less
  SSB (La) (ENA) Antibody, IgG 40 AU/mL or less
  Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG 40 AU/mL or less
  Ribosome P Antibody, IgG 0-40 AU/mL
  Centromere Ab, IgG 0-40 AU/mL
  Scleroderma (Scl-70) (ENA) Antibody, IgG 40 AU/mL or less

Interpretive Data

Refer to report.


Component Interpretation
Smith (ENA) Antibody, IgG 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
Smith/RNP (ENA) Antibody, IgG 19 Units or less
20-39 Units
40-80 Units
81 Units or greater		 Negative
Weak Positive
Moderate Positive
Strong Positive
SSA-52 (Ro52) (ENA) Antibody, IgG 29 AU/mL or Less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
SSA-60 (Ro60) (ENA) Antibody, IgG 29 AU/mL or Less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
SSB (La) (ENA) Antibody, IgG 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
Jo-1 Antibody, IgG 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
Ribosomal P Protein Antibody 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
Centromere Antibody, IgG 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive
Scleroderma (Scl-70) (ENA) Antibody, IgG 29 AU/mL or less
30-40 AU/mL
41 AU/mL or greater		 Negative
Equivocal
Positive

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/21/2023
X
N/A

CPT Codes

86235 x7; 83516 x2

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Components

Component Test Code* Component Chart Name LOINC
0050085 Smith (ENA) Antibody, IgG 18323-6
0050470 Smith/RNP (ENA) Ab, IgG 33983-8
0050599 Scleroderma (Scl-70) (ENA) Antibody, IgG 47322-3
0050691 SSA-52 (Ro52) (ENA) Antibody, IgG 31625-7
0050692 SSB (La) (ENA) Antibody, IgG 29965-1
0050714 Centromere Ab, IgG 29966-9
0099249 Ribosome P Antibody, IgG 13636-6
0099592 Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG 33571-1
2012055 SSA-60 (Ro60) (ENA) Antibody, IgG 53019-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-ENA
  • Anti-RNP
  • Anti-Sm IgG
  • Anti-SSA
  • Anti-SSB
  • Antibodies to Extractable Nuclear Antigens
  • Autoantibodies to Scl 70 Antigen
  • Ribonucleoprotein Autoantibodies
  • Ro Ab
  • Scl 70 Antibodies
  • Scleroderma (Scl-70) (ENA) Antibody, IgG
  • Scleroderma Antibodies
  • Sm/RNP (ENA) Antibody, IgG
  • Smith (ENA) Antibody, IgG
  • Smith Antigen
  • Smith Autoantibodies
  • SmRNP Autoantibodies
  • SSA (Ro) (ENA) Antibody, IgG
  • SSA Ro
  • SSB (La) (ENA) Antibody, IgG
  • SSB LA
Connective Tissue Diseases Profile