Ordering Recommendation

Primarily for research and to support attempts to understand the pathogenesis of immune, infectious, allergic, or inflammatory disorders.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum separator tube, or plain red.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. Ship in an ARUP Standard Transport Tube.

Unacceptable Conditions

Refrigerated specimens. Contaminated or heat-inactivated specimens.


After separation from cells: Ambient: 30 minutes; Refrigerated: Unacceptable; Frozen: 1 year


Quantitative Multiplex Bead Assay




1-4 days

Reference Interval

Test Number
Reference Interval (pg/mL)
  Interleukin 2, Serum 2.1 or less
  Interleukin 2 Receptor, Soluble, Serum 175.3-858.2
  Interleukin 12, Serum 1.9 or less
  Interferon gamma, Serum 4.2 or less

Interpretive Data

Results are used to understand the pathophysiology of immune, infectious, or inflammatory disorders, or may be used for research purposes.

Compliance Category

Laboratory Developed Test (LDT)


Cytokine levels may demonstrate diurnal variation. For longitudinal comparison, it is recommended that cytokine levels be determined at the same time of day.

Hotline History


CPT Codes

83520 x4


Component Test Code* Component Chart Name LOINC
0051529 Interleukin 2 Receptor, Soluble, Serum 76039-7
0051530 Interleukin 12, Serum 41760-0
0051531 Interferon gamma, Serum 27415-9
0051588 Interleukin 2, Serum 33939-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • cytokine
  • cytokines
  • IFN Gamma
  • IL-12
  • IL-2
  • IL-2R
Cytokine Panel, TH1, Serum