Ordering Recommendation

Not recommended as an initial test to evaluate for suspected celiac disease (CD). May be used to evaluate for suspected CD in individuals with negative or weak-positive results for tissue transglutaminase (tTG) IgA and endomysial antibody (EMA) IgA.

The preferred test to screen for CD is Celiac Disease Reflexive Cascade, Serum (3016817).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum separator tube (SST).

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transport 1.0 mL serum. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Contaminated, grossly hemolyzed, grossly icteric, or grossly lipemic.


After separation from cells:  Ambient: 48 hours; Refrigerated: 1 week; Frozen: 30 days


Semi-Quantitative Particle-Based Multianalyte Technology (PMAT)




1-2 days

Reference Interval

Test Number
Reference Interval
  Deamidated Gliadin Peptide (DGP) Ab, IgA 0.00-4.99 FLU

Interpretive Data

A positive deamidated gliadin (DGP) IgA antibody result is associated with celiac disease but is not to be used as an initial screening test due to its low specificity and only occasional positivity in celiac disease patients who are negative for tissue transglutaminase (tTG) IgA antibody.

Compliance Category



In individuals who produce sufficient total IgA, the most sensitive and specific serologic test for celiac disease (CD) diagnosis is tissue transglutaminase (tTG) IgA. Deamidated gliadin peptide (DGP) IgA should not be used for initial screening due to its low specificity and limited role in identifying undetected CD. In individuals who are IgA deficient, tTG IgG and DGP IgG antibody testing is recommended.

Reflexive panel testing is preferred to screen for CD.

Some patients may have positive tTG IgA results but negative endomysial antibody (EMA) IgA and/or DGP IgA results, which may indicate early disease or be associated with false positivity.

All serologic tests used to diagnose CD should be performed while the patient is on a gluten-containing diet. Upon initiation of a gluten-free diet, antibody titers decline in treatment-responsive patients, and the time frame to normalize titers varies by case. If serology is negative and suspicion for CD remains strong, intestinal biopsy may still be warranted to establish a diagnosis.

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0051357 Deamidated Gliadin Peptide (DGP) Ab, IgA 63453-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Celiac Disease Antibodies
  • Coeliac Disease Antibodies
  • Deamidated Gliadin Antibodies (DGP)
  • Deaminated Gliadin Peptide Antibodies
  • DGP
  • DGP Ab
  • DGP IgA
Deamidated Gliadin Peptide (DGP) Antibody, IgA