Ordering Recommendation

May be useful in dosage planning for individuals who will receive high-dose irinotecan, have personal or family history of sensitivity to irinotecan, or have experienced neutropenia while receiving irinotecan. Confirms suspected diagnosis of Gilbert syndrome.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B)

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Ambient.

Unacceptable Conditions
Remarks
Stability

Room temperature: 1 week; Refrigerated: 1 month; Frozen: Unacceptable

Methodology

Polymerase Chain Reaction (PCR)/Fragment Analysis

Performed

Varies

Reported

2-7 days

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

81350

Components

Component Test Code* Component Chart Name LOINC
0051333 UGT1A1 Genotyping Allele 1 51951-2
0051334 UGT1A1 Genotyping Allele 2 51952-0
0051335 UGT1A1 Genotyping Interpretation 34509-0
2001384 UGT1A1 Genotyping Specimen 66746-9
3017864 EER UGT1A1 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Irinotecan Toxiicity
  • UGT1A1
UDP Glucuronosyltransferase 1A1 (UGT1A1) Genotyping