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Prothrombin Antibody, IgG
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Ordering Recommendation
Preferred second-line test when seronegative antiphospholipid syndrome (APS) is strongly suspected. Order incrementally or concurrently with other noncriteria antiphospholipid antibody tests.
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon
Reported
1-8 days
New York DOH Approval Status
Specimen Required
Serum separator tube or lt. blue (sodium citrate).
Transport 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Refrigerated.
Hemolyzed or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval
Effective 5/21/2018
Less than 20 Units
Interpretive Data
IgG antibodies to prothrombin may be a risk factor for either venous or arterial thrombosis in antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies.
If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.
Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.
FDA
Note
Hotline History
CPT Codes
86849
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0051302 | Prothrombin Antibody, IgG | 40595-1 |
Aliases
- Prothrombin IgG
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