Treponema pallidum Antibody, IgG by ELISA

0050920
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Example Reports
Negative
Positive

Ordering Recommendation

Recommended test for syphilis screening (reverse algorithm).

Mnemonic

SYPH G

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Wed

Reported

1-8 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Effective February 16, 2016
0.9 IV or less: Negative - No significant level of Treponema pallidum IgG antibody detected.
1.0 IV: Equivocal - Questionable presence of Treponema pallidum IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.1 IV or greater: Positive - Presence of IgG antibody to Treponema pallidum detected, suggestive of current or past infection.

Interpretive Data

Seroconversion between acute and convalescent sera is considered strong evidence of recent infection. The best evidence for infection is a significant change on two appropriately timed specimens, where both tests are performed in the same laboratory at the same time. The Rapid Plasma Reagin (RPR) with Reflex to RPR Titer or T. pallidum Antibody by Particle Agglutination (2007443) is recommended for follow-up of positive results. For CSF specimens, the Treponema pallidum (VDRL) Cerebrospinal Fluid with Reflex to Titer (0050206) test is recommended.

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/18/2020
X
N/A

CPT Codes

86780

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Components

Component Test Code* Component Chart Name LOINC
0050920 Treponema pallidum Ab, IgG by ELISA 51838-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Syphilis Antibody, IgG by ELISA
  • T pallidum IgG ELISA
Treponema pallidum Antibody, IgG by ELISA