Ordering RecommendationRecommendations when to order or not order the test. May include related or preferred tests.
Not recommended for herpes simplex virus (HSV) testing; IgM lacks adequate predictive value for acute infection. If pursing antibody testing, refer to Herpes Simplex Type 1 and Type 2 Glycoprotein G-Specific Antibodies, IgG by CIA (0051152). If acute HSV infection is suspected, molecular testing is preferred (refer to Herpes Simplex Virus by PCR (0060041)).
ReportedExpected turnaround time for a result, beginning when ARUP has received the specimen.
1-2 days
New York DOH Approval StatusIndicates test has been approved by the New York State Department of Health.
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect
Serum separator tube.
Specimen Preparation
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Refer to individual components. CSF (refer to Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG & IgM (CSF) with Reflex to Type 1 & 2 Glycoprotein G-Specific Ab, IgG, test code 0050364).Refer to individual components.
Remarks
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference IntervalNormal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Test Number
Components
Reference Interval
HSV Type 1/2 Combined Ab, IgG
0.89 IV or less: Not Detected. 0.90-1.09 IV: Indeterminate - Repeat testing in 10-14 days may be helpful. 1.10 IV or greater: Detected.
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM by ELISA
0.89 IV or less:
Not Detected.
0.90-1.09 IV:
Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater:
Detected - IgM antibody to HSV detected, which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by CIA
Effective February 18, 2020
0.89 IV or less
Negative - No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
0.90-1.09 IV
Equivocal - Questionable presence of IgG antibody to HSV type 2 glycoprotein G. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater
Positive - IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or past HSV infection.
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
Refer to individual components for interpretive data.
Compliance Category
FDA
NoteAdditional information related to the test.
If HSV 1 and/or 2 IgG is 1.10 IV or greater, then HSV 1 gG-Specific IgG and HSV 2 gG-Specific IgG will be added. Additional charges apply.
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
AliasesOther names that describe the test. Synonyms.
glycoprotein type-specific reactivity
Herpes Simplex Antibodies, IgG IgM serology
Herpes Simplex serology
HSV F antibody
HSV 1, 2 IgG IgM
HSV 1,2
HSV 1,2 and glycoprotein reflex
HSV 1,2 glycoprotein
HSV glycoprotein G
HSV glycoprotein G-based type-specific serology
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG and IgM with Reflex to Type 1 and 2 Glycoprotein G-Specific Ab, IgG
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