Ordering Recommendation

Not recommended for herpes simplex virus (HSV) testing; IgM lacks adequate predictive value for acute infection. If pursing antibody testing, refer to Herpes Simplex Type 1 and Type 2 Glycoprotein G-Specific Antibodies, IgG by CIA (0051152). If acute HSV infection is suspected, molecular testing is preferred (refer to Herpes Simplex Virus by PCR (0060041)).

Mnemonic
HERPR PAN
Methodology

Semi-Quantitative Chemiluminescent Immunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Refer to individual components. CSF (refer to Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG & IgM (CSF) with Reflex to Type 1 & 2 Glycoprotein G-Specific Ab, IgG, test code 0050364).Refer to individual components.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
Test Number
Components
Reference Interval
  HSV Type 1/2 Combined Ab, IgG 0.89 IV or less: Not Detected.
0.90-1.09 IV: Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Detected.
0050641 Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM by ELISA
0.89 IV or less: Not Detected.
0.90-1.09 IV: Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Detected - IgM antibody to HSV detected, which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.

0050292 Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by CIA
Effective February 18, 2020
0.89 IV or less Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.09 IV Equivocal - Questionable presence of IgG antibody to HSV type 1 glycoprotein G. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past HSV infection.

0050294 Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by CIA
Effective February 18, 2020
0.89 IV or less Negative - No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
0.90-1.09 IV Equivocal - Questionable presence of IgG antibody to HSV type 2 glycoprotein G.  Repeat testing in 10-14 days may be helpful.
1.10 IV or greater Positive - IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or past HSV infection.


Interpretive Data

Refer to individual components for interpretive data.

Compliance Category

FDA

Note

If HSV 1 and/or 2 IgG is 1.10 IV or greater, then HSV 1 gG-Specific IgG and HSV 2 gG-Specific IgG will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

86694 x2; if reflexed, add 86695; 86696

Components
Component Test Code* Component Chart Name LOINC
0050286 HSV Type 1/2 Combined Ab, IgG 27948-9
0050641 HSV 1 and/or 2 Abs, IgM by ELISA 41399-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • glycoprotein type-specific reactivity
  • Herpes Simplex Antibodies, IgG IgM serology
  • Herpes Simplex serology
  • HSV F antibody
  • HSV 1, 2 IgG IgM
  • HSV 1,2
  • HSV 1,2 and glycoprotein reflex
  • HSV 1,2 glycoprotein
  • HSV glycoprotein G
  • HSV glycoprotein G-based type-specific serology
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG and IgM with Reflex to Type 1 and 2 Glycoprotein G-Specific Ab, IgG