Ordering Recommendation

Not a recommended panel for the diagnosis of antiphospholipid syndrome (APS). The combined IgG and IgM Phosphatidylserine test is the preferred second-line testing in seronegative APS.

Mnemonic
PHOS AB
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun, Tue, Wed, Fri, Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month

Reference Interval
Test Number
Components
Reference Interval
0050906 Phosphatidylserine Antibody, IgG Effective Feb 1, 2021
Less than 16 GPS 

GPS: IgG antiphosphatidylserine units
0050907 Phosphatidylserine Antibody, IgM Effective Feb 1, 2021
Less than 22 MPS

MPS: IgM antiphosphatidylserine units
0050908 Phosphatidylserine Antibody, IgA Effective Feb 1, 2021
Less than 20 APS

APS: IgA antiphosphatidylserine units

Interpretive Data

IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and risk for obstetric antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies.

Isolated presence of IgM or IgG antibodies to aPS may have questionable clinical significance for APS and/or SLE.

If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.

Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

86148 x3

Components
Component Test Code* Component Chart Name LOINC
0050906 Phosphatidylserine Antibody IgG 32032-5
0050907 Phosphatidylserine Antibody IgM 32033-3
0050908 Phosphatidylserine Antibody IgA 32031-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-Phosphatidylserine
  • Antiphosphatidylserine
  • aPS Antibodies
  • aPS Antibodies IgG, IgM, IgA
Phosphatidylserine Antibodies, IgG, IgM, and IgA