Ordering Recommendation

Evaluate suspected drug-induced lupus. Negative results do not rule out drug-induced lupus.

Mnemonic
AHA
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Mon, Wed-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or urine. Contaminated specimens. Grossly hemolyzed, icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Effective May 16, 2011

0.9 units or less Negative
1.0-1.5 units Weak Positive
1.6-2.5 units Moderate Positive
2.6 units or greater Strong Positive

Interpretive Data



No compliance statements are in use for this test.

Note

Histone antibodies are present in 20-55% of idiopathic systemic lupus erythematosus (SLE) and 80-95% of drug-induced SLE. They occur in less than 20% of other types of connective tissue diseases.

Hotline History
N/A
Components
Component Test Code* Component Chart Name LOINC
0050860 Histone Antibody, IgG 29996-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AHA IgG, AHA
  • Anti-Histone Antibodies
  • Antihistone Antibodies
  • Histone IgG
Histone Antibody, IgG