0050860
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Histone Antibody, IgG

AHA
Example Reports
Negative
Positive

Ordering Recommendation

Evaluate suspected drug-induced lupus. Negative results do not rule out drug-induced lupus.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or urine. Contaminated specimens. Grossly hemolyzed, icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Mon, Wed-Sat

Reported

1-3 days

Reference Interval

Test Number
 Components
 Reference Interval
  Histone Antibody, IgG 0.9 Units or less

Interpretive Data




Component
 Interpretation
Histone Antibody, IgG 0.9 Units or less               Negative
1.0-1.5 Units                     Weak Positive
1.6-2.5 Units                    Moderate Positive
2.6 Units or greater          Strong Positive

Compliance Category

FDA

Note

Histone antibodies are present in 20-55% of idiopathic systemic lupus erythematosus (SLE) and 80-95% of drug-induced SLE. They occur in less than 20% of other types of connective tissue diseases.

Hotline History

N/A

CPT Codes

83516

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Components

Component Test Code* Component Chart Name LOINC
0050860 Histone Antibody, IgG 29996-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AHA IgG, AHA
  • Anti-Histone Antibodies
  • Antihistone Antibodies
  • Histone IgG
Histone Antibody, IgG