Histone Antibody, IgG
Ordering Recommendation
Evaluate suspected drug-induced lupus. Negative results do not rule out drug-induced lupus.
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon, Wed-Sat
Reported
1-3 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Refrigerated.
Plasma or urine. Contaminated specimens. Grossly hemolyzed, icteric, or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
Effective May 16, 2011
0.9 units or less | Negative |
1.0-1.5 units | Weak Positive |
1.6-2.5 units | Moderate Positive |
2.6 units or greater | Strong Positive |
Interpretive Data
FDA
Note
Histone antibodies are present in 20-55% of idiopathic systemic lupus erythematosus (SLE) and 80-95% of drug-induced SLE. They occur in less than 20% of other types of connective tissue diseases.
Hotline History
CPT Codes
83516
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050860 | Histone Antibody, IgG | 29996-6 |
Aliases
- AHA IgG, AHA
- Anti-Histone Antibodies
- Antihistone Antibodies
- Histone IgG