Evaluate suspected drug-induced lupus. Negative results do not rule out drug-induced lupus.
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Plasma or urine. Contaminated specimens. Grossly hemolyzed, icteric, or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Effective May 16, 2011
|0.9 units or less||Negative|
|1.0-1.5 units||Weak Positive|
|1.6-2.5 units||Moderate Positive|
|2.6 units or greater||Strong Positive|
Histone antibodies are present in 20-55% of idiopathic systemic lupus erythematosus (SLE) and 80-95% of drug-induced SLE. They occur in less than 20% of other types of connective tissue diseases.
|Component Test Code*||Component Chart Name||LOINC|
|0050860||Histone Antibody, IgG||29996-6|
- AHA IgG, AHA
- Anti-Histone Antibodies
- Antihistone Antibodies
- Histone IgG