Treponema pallidum Antibody by TP-PA
CDC-recommended confirmatory test for syphilis. Order if initial screening (eg, RPR, VDRL) is reactive.
Qualitative Particle Agglutination
New York DOH Approval Status
Serum separator tube or plasma separator tube.
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.4 mL)
CSF or other body fluids.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
TP-PA is a helpful diagnostic aid for the patient with a reactive reagin test, but presents with atypical signs of primary, secondary, or late syphilis. TP-PA compares favorably with the FTA test, but appears slightly less sensitive in cases of untreated early primary syphilis. In late syphilis, the agreement with FTA is 99%.
VDRL is the preferred test for cerebrospinal fluid. Treponemal tests (TP-PA or FTA) are not recommended for CSF. FTAs on CSF may be tested, but TP-PA cannot be tested on CSF.
|Component Test Code*||Component Chart Name||LOINC|
|0050777||Treponema pallidum Ab by TP-PA||24312-1|
- Syphilis Antibody by MHA
- Syphilis TPPA
- T pallidum TPPA
- T. pallidum Antibody by MHA
- Treponema Pallidum AB, Particle Agglutination
- Treponema pallidum Particle Agglutination Assay