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Striated Muscle Antibodies, IgG with Reflex to Titer
Ordering Recommendation
Recommended for differential evaluation of neuromuscular junction diseases including myasthenia gravis (MG).
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.15 mL)
Refrigerated.
Plasma. Contaminated, hemolyzed, or severely lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month.
Methodology
Semi-Quantitative Indirect Fluorescent Antibody (IFA)
Performed
Mon-Sat
Reported
1-4 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Striated Muscle Antibodies, IgG Screen | Less than 1:40 |
Interpretive Data
When detected in the presence of acetylcholine receptor (AChR) antibody, striated muscle antibodies, which bind in a cross-striational pattern to skeletal and heart muscle tissue sections, are associated with late-onset myasthenia gravis (MG). Striated muscle antibodies recognize epitopes on three major muscle proteins, including: titin, ryanodine receptor (RyR) and Kv1.4 (an alpha subunit of voltage-gated potassium channel [VGKC]). Isolated cases of striated muscle antibodies may be seen in patients with certain autoimmune diseases, rheumatic fever, myocardial infarction, and following some cardiotomy procedures.
Analyte Specific Reagent (ASR)
Note
If striated muscle antibodies are detected, a titer will be added. Additional charges apply.
Hotline History
CPT Codes
86255; if reflexed, add 86256
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050747 | Striated Muscle Antibodies, IgG Screen | 49692-7 |
Aliases
- Anti-Striated Muscle Antibody
- Anti-Skeletal Muscle IgG Antibodies
- Anti-Striated Antibody
- Muscle (Skeletal) Antibodies
- Myoid Antibody
- Skeletal Muscle Antibodies
- Striational Antibodies
