Extractable Nuclear Antigen Antibodies (Smith/RNP, Smith, SSA 52, SSA 60, and SSB)
Ordering Recommendation
Recommended for the differential diagnosis of systemic lupus erythematosus (SLE) and Sjogren syndrome.
Mnemonic
ENA ABS4
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Semi-Quantitative Multiplex Bead Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect
Serum separator tube.
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Storage/Transport Temperature
Refrigerated..
Unacceptable Conditions
Plasma or other body fluids. Bacterially contaminated or severely lipemic specimens.
Remarks
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)
Reference Interval
Effective May 18, 2015
Test Number |
Components |
Reference Interval |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
0050470 | Smith/RNP (ENA) Antibody, IgG |
|
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0050085 | Smith (ENA) Antibody, IgG |
|
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2012074 | SSA 52 and 60 (Ro) (ENA) Antibodies, IgG |
|
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0050692 | SSB (La) (ENA) Antibody, IgG |
|
Interpretive Data
Refer to report.
Compliance Category
FDA
Note
Hotline History
Hotline History
Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
N/A
CPT Codes
86235 x5
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050085 | Smith (ENA) Antibody, IgG | 18323-6 |
0050470 | Smith/RNP (ENA) Ab, IgG | 33983-8 |
0050691 | SSA-52 (Ro52) (ENA) Antibody, IgG | 31625-7 |
0050692 | SSB (La) (ENA) Antibody, IgG | 29965-1 |
2012055 | SSA-60 (Ro60) (ENA) Antibody, IgG | 53019-6 |
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
- Antibodies to Extractable Nuclear Antigens
- Ro Ab (ENA)
- Ro52
- Ro60 (ENA)
- Sm Smith Autoantibodies
- Sm/RNP (ENA)
- Sm/RNP (ENA) Antibody, IgG
- Smith (ENA) Antibody, IgG
- SmRNP Autoantibodies
- SSA (Ro) (ENA) Antibody, IgG
- SSA Ro
- SSA-52
- SSA-60
- SSB (La) (ENA) Antibody, IgG
- Topo-1
- topoisomerase 1
Extractable Nuclear Antigen Antibodies (Smith/RNP, Smith, SSA 52, SSA 60, and SSB)