Ordering Recommendation
Aid in the diagnosis and management of monoclonal gammopathies, including multiple myeloma. Use to detect and quantify serum monoclonal protein.
Mnemonic
Methodology
Quantitative Capillary Electrophoresis/Colorimetry
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)
Refrigerated.
Plasma.
After separation from cells: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month
Reference Interval
Effective August 19, 2019
Test Number |
Components |
Reference Interval |
---|---|---|
Total Protein, Serum | Refer to report. Reference intervals may vary based on instrumentation. | |
Albumin | 3.75-5.01 g/dL | |
Alpha 1 Globulin | 0.19-0.46 g/dL | |
Alpha 2 Globulin | 0.48-1.05 g/dL | |
Beta Globulin | 0.48-1.10 g/dL | |
Gamma | 0.62-1.51 g/dL |
Interpretive Data
Serum protein electrophoresis, when used as a screening test, is useful in the detection of various pathophysiologic states such as inflammation, protein loss, gammopathies, and other dysproteinemias. However, immunofixation electrophoresis (IFE) is a more sensitive technique for the identification of small M-proteins found in patients with amyloidosis, early or treated myeloma or macroglobulinemia, solitary plasmacytoma, or extramedullary plasmacytoma.
FDA
Note
A copy of the graph will follow final report.
For CSF electrophoresis, refer to Protein Electrophoresis, CSF (ARUP test code 0050590).
Hotline History
Hotline History
CPT Codes
84155; 84165
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050020 | Albumin | 2862-1 |
0050035 | Alpha 1 Globulin | 2865-4 |
0050060 | Alpha 2 Globulin | 2868-8 |
0050110 | Beta Globulin | 2871-2 |
0050270 | Gamma | 2874-6 |
0050545 | Total Protein, Serum | 2885-2 |
2005168 | SPEP/IFE Interpretation | 49275-1 |
2011827 | Monoclonal Protein | 33358-3 |
2012453 | EER Protein Electrophoresis, Serum | 11526-1 |
Aliases
- Protein ELP
- Serum Protein Electrophoresis
- SPEP