Ordering Recommendation

Aid as second order test for evaluation of patients suspected of humoral immunodeficiency or combined immunodeficiency (humoral or cellular).

Mnemonic

IGG SUB

Methodology

Quantitative Immunoturbidimetry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Grossly hemolyzed or lipemic specimens

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 6 months

Reference Interval

Test Number
Components
Reference Interval
  Immunoglobulin G Subclass 1
Age Reference Interval (mg/dL)
0-2 years 167-900
3-4 years 313-941
5-9 years 363-1276
10-14 years 316-1076
15-18 years 325-894
19 years and older 240-1118

  Immunoglobulin G Subclass 2
Age
Reference Interval (mg/dL)
0-2 years 55-359
3-4 years 72-287
5-9 years 27-398
10-14 years 86-509
15-18 years 156-625
19 years and older 124-549

  Immunoglobulin G Subclass 3
Age Reference Interval (mg/dL)
0-2 years 34-85
3-4 years 25-117
5-9 years 17-169
10-14 years 14-201
15-18 years 34-246
19 years and older 21-134

  Immunoglobulin G Subclass 4
Age
Reference Interval (mg/dL)
0-2 years 1-34
3-4 years 1-65
5-9 years 0-168
10-14 years 1-103
15-18 years 2-170
19 years and older 1-123

Interpretive Data

The total IgG (mg/dL) can be derived from the sum of the subclass IgG1, IgG2, IgG3, and IgG4 values. However, a confirmatory and more precise total IgG is available by the immunoturbidimetric method of quantitation for total IgG.  Refer to test Immunoglobulin G, Serum (0050350).

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

82787 x4

Components

Component Test Code* Component Chart Name LOINC
0050571 Immunoglobulin G Subclass 1 2466-1
0050572 Immunoglobulin G Subclass 2 2467-9
0050573 Immunoglobulin G Subclass 3 2468-7
0050576 Immunoglobulin G Subclass 4 2469-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Gamma-Globulins, Quantitative
  • IgG 1, 2, 3, 4
  • IgG Subclasses
  • Subclasses, IgG
Immunoglobulin G Subclasses (1, 2, 3, 4)