Ordering Recommendation

Aid as second order test for evaluation of patients suspected of humoral immunodeficiency or combined immunodeficiency (humoral or cellular).

Mnemonic

IGG SUB

Methodology

Quantitative Immunoturbidimetry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Grossly hemolyzed or lipemic specimens

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 6 months

Reference Interval

Test Number
Components
Reference Interval
  Immunoglobulin G Subclass 1 Effective February 16, 2021
0-2 years: 167-900 mg/dL
3-4 years: 313-941 mg/dL
5-9 years: 363-1276 mg/dL
10-14 years: 316-1076 mg/dL
15-18 years: 325-894 mg/dL
19 years and older: 240-1118 mg/dL
  Immunoglobulin G Subclass 2 Effective February 16, 2021
0-2 years: 55-359 mg/dL
3-4 years: 72-287 mg/dL
5-9 years: 27-398 mg/dL
10-14 years: 86-509 mg/dL
15-18 years: 156-625 mg/dL
19 years and older: 124-549 mg/dL
  Immunoglobulin G Subclass 3 Effective February 16, 2021
0-2 years: 34-85 mg/dL
3-4 years: 25-117 mg/dL
5-9 years: 17-169 mg/dL
10-14 years: 14-201 mg/dL
15-18 years: 34-246 mg/dL
19 years and older: 21-134 mg/dL
0050576 Immunoglobulin G Subclass 4 Effective February 16, 2021
0-2 years: 1-34 mg/dL                      
3-4 years: 1-65 mg/dL                         
5-9 years: 0-168 mg/dL                         
10-14 year: 1-103 mg/dL                    
15-18 years: 2-170 mg/dL                              
19 years and older: 1-123 mg/dL

Interpretive Data

The total IgG (mg/dL) can be derived from the sum of the subclass IgG1, IgG2, IgG3, and IgG4 values. However, a confirmatory and more precise total IgG is available by the immunoturbidimetric method of quantitation for total IgG.  Refer to test Immunoglobulin G, Serum (0050350).

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

82787 x4

Components

Component Test Code* Component Chart Name LOINC
0050571 Immunoglobulin G Subclass 1 2466-1
0050572 Immunoglobulin G Subclass 2 2467-9
0050573 Immunoglobulin G Subclass 3 2468-7
0050576 Immunoglobulin G Subclass 4 2469-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Gamma-Globulins, Quantitative
  • IgG 1, 2, 3, 4
  • IgG Subclasses
  • Subclasses, IgG
Immunoglobulin G Subclasses (1, 2, 3, 4)