Ordering Recommendation

Do not order for total IgG measurements. Secondary test in suspected immunoglobulin deficiency. Do not order before IgG, IgA, and IgM measurements are performed.

Mnemonic
IGG SUB
Methodology

Quantitative Nephelometry

Performed

Mon-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.45 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

After separation from cells: Ambient: 2 hours; Refrigerated: 8 days; Frozen: 6 months

Reference Interval
Test Number
Components
Reference Interval
0050571 Immunoglobulin G Subclass 1 Cord blood: 435-1084 mg/dL                 5-6 years: 330-1065 mg/dL
0-2 months: 218-498 mg/dL                   7-8 years: 225-1100 mg/dL
3-5 months: 143-394 mg/dL                   9-10 years: 390-1235 mg/dL
6-8 months: 190-388 mg/dL                   11-12 years: 380-1420 mg/dL
9-23 months: 288-880 mg/dL                 13-14 years: 165-1440 mg/dL
2 years: 170-950 mg/dL                          15 years and older: 240-1118 mg/dL
3-4 years: 290-1065 mg/dL
0050572 Immunoglobulin G Subclass 2 Cord blood: 143-453 mg/dL                   5-6 years: 57-345 mg/dL
0-2 months: 40-167 mg/dL                     7-8 years: 42-375 mg/dL
3-5 months: 23-147 mg/dL                     9-10 years: 61-430 mg/dL
6-8 months: 37-60 mg/dL                       11-12 years: 73-455 mg/dL
9-23 months: 30-327 mg/dL                   13-14 years: 71-460 mg/dL
2 years: 22-440 mg/dL                            15 years and older: 124-549 mg/dL
3-4 years: 28-315 mg/dL
0050573 Immunoglobulin G Subclass 3 Cord blood: 27-146 mg/dL                     5-6 years: 8-126 mg/dL
0-2 months: 4-23 mg/dL                         7-8 years: 9-107 mg/dL
3-5 months: 4-70 mg/dL                         9-10 years: 10-98 mg/dL
6-8 months: 12-62 mg/dL                       11-12 years: 16-194 mg/dL
9-23 months: 13-82 mg/dL                     13-14 years: 12-178 mg/dL
2 years: 4-69 mg/dL                                15 years and older: 21-134 mg/dL
3-4 years: 4-71 mg/dL
0050576 Immunoglobulin G Subclass 4 Effective February 16, 2016
Cord blood: 1-47 mg/dL                         5-6 years: 2-116 mg/dL
0-2 months: 1-33 mg/dL                         7-8 years: 0-138 mg/dL
3-5 months: 1-14 mg/dL                         9-10 years: 1-95 mg/dL
6-8 months: 1-16 mg/dL                         11-12 years: 1-153 mg/dL
9-23 months: 1-65 mg/dL                       13-14 years: 2-143 mg/dL
2 years: 0-120 mg/dL                              15 years and older: 1-123 mg/dL
3-4 years: 0-90 mg/dL

Interpretive Data

The total IgG (mg/dL) can be derived from the sum of the subclass IgG1, IgG2, IgG3, and IgG4 values. However, a confirmatory and more precise total IgG is available by the nephelometric method of quantitation for total IgG.  Refer to test Immunoglobulin G, Serum (0050350).

No compliance statements are in use for this test.

Note
Hotline History
N/A
CPT Codes

82787 x4

Components
Component Test Code* Component Chart Name LOINC
0050571 Immunoglobulin G Subclass 1 2466-1
0050572 Immunoglobulin G Subclass 2 2467-9
0050573 Immunoglobulin G Subclass 3 2468-7
0050576 Immunoglobulin G Subclass 4 2469-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Gamma-Globulins, Quantitative
  • IgG 1, 2, 3, 4
  • IgG Subclasses
  • Subclasses, IgG
Immunoglobulin G Subclasses (1, 2, 3, 4)