Immunoglobulin G Subclasses (1, 2, 3, 4)

0050577
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Example Reports
Abnormal
Normal

Ordering Recommendation

Aid as second order test for evaluation of patients suspected of humoral immunodeficiency or combined immunodeficiency (humoral or cellular).

Mnemonic

IGG SUB

Methodology

Quantitative Immunoturbidimetry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Grossly hemolyzed or lipemic specimens

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 6 months

Reference Interval

Test Number
 Components
 Reference Interval
  Immunoglobulin G Subclass 1 Effective February 16, 2021
0-2 years: 167-900 mg/dL
3-4 years: 313-941 mg/dL
5-9 years: 363-1276 mg/dL
10-14 years: 316-1076 mg/dL
15-18 years: 325-894 mg/dL
19 years and older: 240-1118 mg/dL
  Immunoglobulin G Subclass 2 Effective February 16, 2021
0-2 years: 55-359 mg/dL
3-4 years: 72-287 mg/dL
5-9 years: 27-398 mg/dL
10-14 years: 86-509 mg/dL
15-18 years: 156-625 mg/dL
19 years and older: 124-549 mg/dL
  Immunoglobulin G Subclass 3 Effective February 16, 2021
0-2 years: 34-85 mg/dL
3-4 years: 25-117 mg/dL
5-9 years: 17-169 mg/dL
10-14 years: 14-201 mg/dL
15-18 years: 34-246 mg/dL
19 years and older: 21-134 mg/dL
0050576 Immunoglobulin G Subclass 4 Effective February 16, 2021
0-2 years: 1-34 mg/dL                      
3-4 years: 1-65 mg/dL                         
5-9 years: 0-168 mg/dL                         
10-14 year: 1-103 mg/dL                    
15-18 years: 2-170 mg/dL                              
19 years and older: 1-123 mg/dL

Interpretive Data

The total IgG (mg/dL) can be derived from the sum of the subclass IgG1, IgG2, IgG3, and IgG4 values. However, a confirmatory and more precise total IgG is available by the immunoturbidimetric method of quantitation for total IgG.  Refer to test Immunoglobulin G, Serum (0050350).

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/16/2021
X
X
X
X
X
N/A

CPT Codes

82787 x4

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Components

Component Test Code* Component Chart Name LOINC
0050571 Immunoglobulin G Subclass 1 2466-1
0050572 Immunoglobulin G Subclass 2 2467-9
0050573 Immunoglobulin G Subclass 3 2468-7
0050576 Immunoglobulin G Subclass 4 2469-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Gamma-Globulins, Quantitative
  • IgG 1, 2, 3, 4
  • IgG Subclasses
  • Subclasses, IgG
Immunoglobulin G Subclasses (1, 2, 3, 4)