Ordering Recommendation

First-line test for identifying visceral T. gondii infection. CDC suggests equivocal or positive results should be retested using a different assay from another reference laboratory specializing in toxoplasmosis testing (IgG dye test, IgM ELISA, reflex to avidity and/or other tests).

Mnemonic
TOXO PAN
Methodology

Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or urine. Contaminated, heat-inactivated or grossly hemolyzed specimens.

Remarks

Label specimens plainly as "acute" or "convalescent."

Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
Test Number
Components
Reference Interval
0050770 Toxoplasma gondii Antibody, IgG Effective March 3, 2014
7.1 IU/mL or less: Not Detected.
7.2-8.7 IU/mL: Indeterminate - Repeat testing in 10-14 days may be helpful.
8.8 IU/mL or greater: Detected.

0050557 Toxoplasma gondii Antibody, IgM
7.9 AU/mL or less: Not Detected.
8.0-9.9 AU/mL: Indeterminate - Repeat testing in 10-14 days may be helpful.
10.0 AU/mL or greater: Detected - Significant level of Toxoplasma gondii IgM antibody detected and may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.


Interpretive Data

Refer to report.

Compliance Category

FDA

Note

This test should not be used for blood donor screening, associated re-entry protocols, or for screening Human Cell, Tissues and Cellular and Tissue-Based Products (HCT/P).

Hotline History
N/A
CPT Codes

86777; 86778

Components
Component Test Code* Component Chart Name LOINC
0050557 Toxoplasma gondii Ab, IgM 8040-8
0050770 Toxoplasma gondii Ab, IgG 8039-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CMV Antibody IgM
  • HSV 1 and/or 2 Abs, IgM by ELISA’ TORCH IgM panel
  • Rubella Antibody IgM
  • Toxoplasma gondii Ab, IgM
Toxoplasma gondii Antibodies, IgG and IgM