Rickettsia typhi (Typhus Fever) Antibodies, IgG & IgM by IFA

0050384
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Negative
Positive

Ordering Recommendation

Confirm presence of Rickettsia typhi. Requires comparison of acute- to convalescent-phase serology.

Mnemonic

TYPHU G/M

Methodology

Semi-Quantitative Indirect Fluorescent Antibody

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, hemolyzed, or severely lipemic specimens.

Remarks

Mark specimens plainly as "acute" or "convalescent."

Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
 Components
 Reference Interval
  Typhus Fever Antibody, IgG Less than 1:64
  Typhus Fever Antibody, IgM Less than 1:64

Interpretive Data




Component Interpretation
Rickettsia typhi (Typhus Fever) Antibody, IgG by IFA Less than 1:64   Negative - No significant level of IgG antibody detected.
1:64-1:128    Equivocal - Questionable presence of IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1:256 or greater   Positive - Presence of IgG antibody detected, suggestive of current or past infection
Rickettsia typhi (Typhus Fever) Antibody, IgM by IFA Less than 1:64   Negative - No significant level of IgM antibody detected.
1:64 or greater   Positive - Presence of IgM antibody to detected, which may indicate a current or recent infection; however, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86757 x2

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Components

Component Test Code* Component Chart Name LOINC
0050381 Typhus Fever Antibody, IgG 5324-9
0050383 Typhus Fever Antibody, IgM 5325-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Murine Typhus Antibodies
  • R. typhi antibodies
  • Typhus Fever Group Antibody, IgG and IgM, Serum
Rickettsia typhi (Typhus Fever) Antibodies, IgG & IgM by IFA