Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF
Not a stand-alone test. Molecular testing is preferred (refer to Herpes Simplex Virus by PCR (0060041)).
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Mon, Wed, Fri
Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.2 mL)
Specimen types other than CSF. Contaminated, heat-inactivated, or hemolyzed specimens.
Indicate source on test request form.
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year
|0.89 IV or less||Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.|
|0.90-1.10 IV||Equivocal - Questionable presence of IgG antibody to HSV type 1. Repeat testing in 10-14 days may be helpful.|
|1.11 IV or greater||Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past infection.|
Individuals infected with HSV may not exhibit detectable IgG antibody to type-specific HSV antigens 1 and 2 in the early stages of infection. Detection of antibody presence in these cases may only be possible using a nontype-specific screening test.
The detection of antibodies to herpes simplex virus in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.
Fourfold or greater rise in CSF antibodies to herpes on specimens at least 4 weeks apart are found in 74-94 percent of patients with herpes encephalitis. Specificity of the test based on a single CSF testing is not established. Presently PCR is the primary means of establishing a diagnosis of herpes encephalitis.
Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
|Component Test Code*||Component Chart Name||LOINC|
|0050379||HSV Type 1 Antibody IgG, CSF||48399-0|
- HSV 1 CSF
- HSV type 1 glycoprotein G, CSF
- HSV typing CSF