Ordering Recommendation

Detect circulating immune complexes.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Plain red or serum separator tube (SST)

Specimen Preparation

Allow complete clotting of red blood cells (up to 1 hour), then separate serum from cells within 30 minutes and freeze immediately. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL) If ordered in conjunction with a Circulating Immune Complex, C3 fragments, transfer TWO (2) 1 mL aliquots of serum to individual ARUP Standard Transport Tubes.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Non-frozen specimens.


After separation from cells: Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks (avoid repeated freeze/thaw cycles)


Semi-Quantitative Enzyme-Linked Immunosorbent Assay


Mon, Thu, Sat


2-9 days

Reference Interval

Effective February 19, 2019
Less than or equal to 3.9 µg Eq/mL

Interpretive Data

Less than or equal to 3.9 µg Eq/mL is considered negative for circulating complement binding immune complexes. Circulating immune complexes may be found without any evident pathology and positive results do not necessarily implicate the immune complex in a disease process.

Compliance Category



Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0050301 Circulating Immune Complex, C1q Binding 27831-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • CIC
  • Circulating complement binding immune complex
  • Immune Complex Assay
Circulating Immune Complex, C1q Binding