West Nile Virus Antibody, IgM by ELISA, CSF

0050239
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Example Reports
Negative
Positive

Ordering Recommendation

Preferred test for diagnosing West Nile encephalitis.

Mnemonic

WNIL IGM

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun, Tue, Fri

Reported

1-6 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 2 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Bacterially contaminated, heat-inactivated, hemolyzed or xanthochromic specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

0.89 IV or less Negative - No significant level of West Nile virus IgM antibody detected.
0.90-1.10 IV Equivocal - Questionable presence of West Nile virus IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater Positive - Presence of IgM antibody to West Nile virus detected, suggestive of current or recent infection.

Interpretive Data

This test is intended to be used as a semi-quantitative means of detecting West Nile virus-specific IgM in CSF specimens in which there is a clinical suspicion of West Nile virus infection.  This test should not be used solely for quantitative purposes, nor should the results be used without correlation to clinical history or other data.  Because other members of the Flaviviridae family, such as St. Louis encephalitis virus, show extensive cross-reactivity with West Nile virus, serologic testing specific for these species should be considered.

The detection of antibodies to West Nile virus in cerebrospinal fluid may indicate central nervous system infection.  However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/15/2022
X
N/A

CPT Codes

86788

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Components

Component Test Code* Component Chart Name LOINC
0050239 West Nile Virus Antibody IgM CSF 39573-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Arbovirus
  • Flavivirus
  • WNV IgM CSF
West Nile Virus Antibody, IgM by ELISA, CSF