Preferred test for diagnosing West Nile encephalitis.
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Sun, Tue, Fri
New York DOH Approval Status
Transfer 2 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Bacterially contaminated, heat-inactivated, hemolyzed or xanthochromic specimens.
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
|0.89 IV or less||Negative - No significant level of West Nile virus IgM antibody detected.|
|0.90-1.10 IV||Equivocal - Questionable presence of West Nile virus IgM antibody detected. Repeat testing in 10-14 days may be helpful.|
|1.11 IV or greater||Positive - Presence of IgM antibody to West Nile virus detected, suggestive of current or recent infection.|
This test is intended to be used as a semi-quantitative means of detecting West Nile virus-specific IgM in CSF specimens in which there is a clinical suspicion of West Nile virus infection. This test should not be used solely for quantitative purposes, nor should the results be used without correlation to clinical history or other data. Because other members of the Flaviviridae family, such as St. Louis encephalitis virus, show extensive cross-reactivity with West Nile virus, serologic testing specific for these species should be considered.
The detection of antibodies to West Nile virus in cerebrospinal fluid may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0050239||West Nile Virus Antibody IgM CSF||39573-1|
- WNV IgM CSF