West Nile Virus Antibody, IgM by ELISA, CSF

0050239
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Example Reports
Negative
Positive
Ordering Recommendation

Preferred test for diagnosing West Nile encephalitis.

Mnemonic
WNIL IGM
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun, Tue, Fri

Reported

1-6 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 2 mL CSF to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated, or hemolyzed specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
0.89 IV or less Negative - No significant level of West Nile virus IgM antibody detected.
0.90-1.10 IV Equivocal - Questionable presence of West Nile virus IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater Positive - Presence of IgM antibody to West Nile virus detected, suggestive of current or recent infection.

Interpretive Data

This test is intended to be used as a semi-quantitative means of detecting West Nile virus-specific IgM in CSF specimens in which there is a clinical suspicion of West Nile virus infection.  This test should not be used solely for quantitative purposes, nor should the results be used without correlation to clinical history or other data.  Because other members of the Flaviviridae family, such as St. Louis encephalitis virus, show extensive cross-reactivity with West Nile virus, serologic testing specific for these species should be considered.

The detection of antibodies to West Nile virus in cerebrospinal fluid may indicate central nervous system infection.  However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
CPT Codes

86788

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Components
Component Test Code* Component Chart Name LOINC
0050239 West Nile Virus Antibody IgM CSF 39573-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Arbovirus
  • Flavivirus
  • WNV IgM CSF
West Nile Virus Antibody, IgM by ELISA, CSF