0050225
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Epstein-Barr Virus Antibody to Early D Antigen (EA-D), IgG

EBV EAD
Example Reports
Detected
Not Detected

Ordering Recommendation

May aid in the diagnosis of acute Epstein-Barr virus (EBV) infection and EBV reactivation in conjunction with other serologic studies. Molecular tests are preferred to detect EBV reactivation. Not a standalone test.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated,  heat-inactivated, icteric, or grossly hemolyzed specimens.

Remarks

Label specimens plainly as "acute" or "convalescent."

Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Methodology

Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

1-2 days

Reference Interval

Test Number
 Test Name
 Reference Interval
0050225 EBV Antibody to Early (D) Antigen IgG <=8.9 U/mL

Interpretive Data

8.9 U/mL or less: Not Detected
9.0-10.9 U/mL: Indeterminate - Repeat testing in 10-14 days may be helpful.
11.0 U/mL or greater: Detected

Compliance Category

FDA

Note

EBV EA-D values obtained with different manufacturers' assay methods may not be used interchangeably.  The magnitude of the reported EBV EA-D level cannot be correlated to an endpoint titer.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
07/21/2025
X
X
N/A

CPT Codes

86663

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Components

Component Test Code* Component Chart Name LOINC
0050225 EBV Antibody to Early (D) Antigen IgG 50969-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • EBNA Antibody
  • EBV Nuclear Antibody
  • EA-D IgG Ab
  • EBNA to EA-D
  • EAD Ab
  • EBV Antibody to Early D Antigen
Epstein-Barr Virus Antibody to Early D Antigen (EA-D), IgG