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Cryofibrinogen
Ordering Recommendation
Aids in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.
New York DOH Approval Status
Specimen Required
Fasting specimen required: Overnight or minimum of 8 hours fasting.
Whole blood drawn in a prewarmed (37°C) syringe. Specimen may be drawn directly into a prewarmed lt. blue (sodium citrate) or black (sodium citrate).
Maintain whole blood at 37°C from collection to transport; do not refrigerate or freeze at any time. Immediately after blood has been obtained, transfer specimen to a prewarmed blue (sodium citrate) or black (sodium citrate) (if not used for collection). Separate plasma from cells using a 37°C centrifuge, if possible. Transfer 3 mL plasma to an ARUP standard transport tube. (Min: 1 mL)
Room temperature. Also acceptable: Refrigerated.
Serum. Heparinized plasma. Grossly hemolyzed or lipemic specimens.
Proper collection and transport of specimen is critical to the outcome of the assay. Quantities less than 3 mL may affect the sensitivity of the assay.
After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable
Methodology
Qualitative Cold Precipitation
Performed
Sun-Sat
Reported
3-5 days
Reference Interval
Negative at 72 hours.
Interpretive Data
Standard
Note
Hotline History
CPT Codes
82585
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050190 | Cryofibrinogen | 29744-0 |
Aliases
- cryofibrinogen protein
- plasma cryofibrinogen
- Cryofibrinogen, Qualitative, Plasma
- cryopreciptate
- Cryoprotein
