Ordering RecommendationRecommendations when to order or not order the test. May include related or preferred tests.
Aids in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.
MnemonicUnique test identifier.
CRYGB
MethodologyProcess(es) used to perform the test.
Qualitative Cold Precipitation
PerformedDays of the week the test is performed.
Sun-Sat
ReportedExpected turnaround time for a result, beginning when ARUP has received the specimen.
3-5 days
New York DOH Approval StatusIndicates test has been approved by the New York State Department of Health.
This test is New York DOH approved.
Specimen Required
Patient Preparation
Fasting specimen required.
Collect
Plain red tube.
Specimen Preparation
1) Draw approximately 7 mL of blood into a pre-warmed (37°C) plain red tube. Alternatively: draw into a pre-warmed (37°C) syringe and immediately transfer blood to a pre-warmed (37°C) plain red tube. 2) Maintain collected blood at 37°Cuntil clotting is complete. 3) Separate serum from cells within 1 hour of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) See Remarks.
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated.
Unacceptable Conditions
Plasma. Serum separator tubes (SST or clot-activating tubes). Grossly hemolyzed or lipemic specimens.
Remarks
Proper collection and transport of specimen is critical to the outcome of the test. Submitting quantities less than 3 mL may affect the sensitivity of the test.
Stability
After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable
Reference IntervalNormal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Negative at 72 hours.
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
Compliance Category
Standard
NoteAdditional information related to the test.
The specimen is examined daily for the presence or absence of cryoglobulins over a period of three days. Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular diseases, hepatitis C infection and infections such as infectious mononucleosis and cytomegalovirus disease. They may also be found in low levels in apparently healthy individuals.
Hotline History
N/A
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
AliasesOther names that describe the test. Synonyms.