Ordering Recommendation

Aids in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.

Mnemonic
CRYGB
Methodology

Qualitative Cold Precipitation

Performed

Sun-Sat

Reported

3-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Fasting specimen required.

Collect

Plain red tube.

Specimen Preparation

1) Draw approximately 7 mL of blood into a pre-warmed (37°C) plain red tube. Alternatively: draw into a pre-warmed (37°C) syringe and immediately transfer blood to a pre-warmed (37°C) plain red tube. 2) Maintain collected blood at 37°C until clotting is complete. 3) Separate serum from cells within 1 hour of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) See Remarks.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated.

Unacceptable Conditions

Plasma. Serum separator tubes (SST or clot-activating tubes). Grossly hemolyzed or lipemic specimens.

Remarks

Proper collection and transport of specimen is critical to the outcome of the test. Submitting quantities less than 3 mL may affect the sensitivity of the test.

Stability

After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

Negative at 72 hours.

Interpretive Data



No compliance statements are in use for this test.

Note

The specimen is examined daily for the presence or absence of cryoglobulins over a period of three days. Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular diseases, hepatitis C infection and infections such as infectious mononucleosis and cytomegalovirus disease. They may also be found in low levels in apparently healthy individuals.

Hotline History
N/A
CPT Codes

82595

Components
Component Test Code* Component Chart Name LOINC
0050185 Cryoglobulin, Qualitative 5117-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cryoglobulins/cryoglobulins
  • Cryoprotein
  • Qualitative cryoglobulin
Cryoglobulin, Qualitative