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Cryoglobulin, Qualitative
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Ordering Recommendation
Aids in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.
Mnemonic
Methodology
Qualitative Cold Precipitation
Performed
Sun-Sat
Reported
3-5 days
New York DOH Approval Status
Specimen Required
Fasting specimen required.
Plain red tube.
1) Draw approximately 7 mL of blood into a pre-warmed (37°C) plain red tube. Alternatively: draw into a pre-warmed (37°C) syringe and immediately transfer blood to a pre-warmed (37°C) plain red tube. 2) Maintain collected blood at 37°C until clotting is complete. 3) Separate serum from cells within 1 hour of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) See Remarks.
Room temperature. Also acceptable: Refrigerated.
Plasma. Serum separator tubes (SST or clot-activating tubes). Grossly hemolyzed or lipemic specimens.
Proper collection and transport of specimen is critical to the outcome of the test. Submitting quantities less than 3 mL may affect the sensitivity of the test.
After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable
Reference Interval
Negative at 72 hours.
Interpretive Data
Standard
Note
The specimen is examined daily for the presence or absence of cryoglobulins over a period of three days. Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular diseases, hepatitis C infection and infections such as infectious mononucleosis and cytomegalovirus disease. They may also be found in low levels in apparently healthy individuals.
Hotline History
CPT Codes
82595
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050185 | Cryoglobulin, Qualitative | 5117-7 |
Aliases
- Cryoglobulins/cryoglobulins
- Cryoprotein
- Qualitative cryoglobulin
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