Ordering Recommendation

Not recommended for general cardiovascular disease risk assessment in asymptomatic adults. May aid in CVD risk stratification in specific populations.

Mnemonic
HSCRP
Methodology

Quantitative Immunoturbidimetry

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube. Also acceptable: Plasma separator tube, pink (K2EDTA), or green (lithium heparin).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: 11 days; Refrigerated: 2 months; Frozen: 1 year

Reference Interval

3.0 mg/L or less

Interpretive Data

Patients with higher hs-CRP concentrations are more likely to develop stroke, myocardial infarction, and severe peripheral vascular disease. 

CRP is a nonspecific marker of inflammation and a variety of conditions other than atherosclerosis may cause elevated concentrations. If the first result is greater than 3.0 mg/L, recommend repeating test at least 2 weeks later in a metabolically stable state, free of infection or acute illness.  The lower of the two results should be used to determine the patient's risk.

Significantly decreased CRP values may result in specimens from patients treated with carboxypenicillins.


hs-CRP results are used to assign risk as follows (Clin Chem 2009; 55:378-84):
Less than 1.0 mg/L
1.0-3.0 mg/L
3.1-9.9 mg/L
Greater than 9.9 mg/L
Low risk
Average risk
High risk
Very high risk

No compliance statements are in use for this test.

Note
Hotline History
N/A
CPT Codes

86141

Components
Component Test Code* Component Chart Name LOINC
0050182 CRP, High Sensitivity 30522-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • C Reactive Protein, Cardiac
  • C Reactive Protein, High Sensitivity
  • C-Reactive Prot, High Sens, Serum
  • C-Reactive Protein, Cardio
  • C-Reactive Protein, Sensitive
  • Cardio C-Reactive Protein
  • CRP Cardiac
  • CRP High Sensitivity
  • CRP, High Sensitivity
  • High Sensitivity, CRP
  • High-sensitivity CRP
  • HSCRP
  • Ultra-sensitive CRP
C-Reactive Protein, High Sensitivity