Ordering Recommendation

Provide evidence of vaccination or past infection with varicella-zoster virus.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum Separator Tube (SST).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature


Unacceptable Conditions

Contaminated, heat-inactivated, grossly hemolyzed, lipemic, or severely icteric specimens.


Label specimens plainly as acute or convalescent.


After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (Avoid repeated freeze/thaw cycles)


Semi-Quantitative Chemiluminescent Immunoassay




Within 24 hours

Reference Interval

Effective February 18, 2020

134.9 IV or less: Negative - No significant level of detectable varicella-zoster IgG antibody.
135.0-164.9 IV: Equivocal - Repeat testing in 10-14 days may be helpful.
165.0 IV or greater: Positive - IgG antibody to varicella-zoster detected, which may indicate a current or past varicella-zoster infection.

Interpretive Data

The best evidence for current infection is a significant change on two appropriately timed specimens, where both tests are done in the same laboratory at the same time.

Compliance Category



For CSF specimens, refer to Varicella-Zoster Virus Antibody, IgG, CSF (ARUP test code 0054444).

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0050167 Varicella-Zoster Virus Ab, IgG 5403-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Herpes Zoster
  • Herpes Zoster Antibodies
  • IgG, Serum
  • Varicella-Zoster Antibody
  • Varicella-Zoster Antibody Screen
  • Varicella-zoster IgG
  • Varicella-Zoster Immune Status
  • VZ AB IgG
  • VZ Ab, IgG
  • VZV
  • VZV Antibody, IgG
Varicella-Zoster Virus Antibody, IgG