Ordering Recommendation

May assist in ruling out a complement deficiency.

Mnemonic

C4

Methodology

Quantitative Immunoturbidimetry

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube. Also acceptable: Lavender (EDTA), pink (K2EDTA), or green (lithium heparin).

Specimen Preparation

Allow specimen to clot at room temperature. Separate serum from cells ASAP or within 2 hours of collection and freeze. Transport 0.5 mL serum. (Min: 0.3 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Specimens left to clot at refrigerated temperature. Specimens exposed to repeated freeze/thaw cycles.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 8 days; Frozen: 3 months (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
Components
Reference Interval
  Complement Component 4
Age Reference Interval (mg/dL)
0-30 days 8-30
1 month 9-33
2 months 9-37
3 months 10-35
4 months 10-49
5 months 9-48
6 months 12-55
7-8 months 13-48
9-11 months 16-51
1 year 16-52
2-4 years 12-47
5-11 years 13-44
12-17 years 14-41
18 years and older 10-40

Interpretive Data



Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86160

Components

Component Test Code* Component Chart Name LOINC
0050155 Complement Component 4 4498-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 4th Component of Complement, Serum
  • C4
  • C4 Complement Serum
  • C4, Serum
  • Complement C4, Serum
  • Fourth Component of Complement
Complement Component 4