Estrogen/Progesterone Receptor with Interpretation by Immunohistochemistry

0049210
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Example Reports
Negative
Positive

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Immunohistochemistry Stain Form Recommended (ARUP form #32978)

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Supplemental Resources
Ordering Recommendation

Aid in the prediction of response to antiestrogen agents for patients with ductal carcinoma in situ (DCIS) and invasive cancers.

Mnemonic
ERPR IP
Methodology

Immunohistochemistry

Performed

Mon-Fri

Reported

Within 4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue no later than 1 hour after removal from patient. Fixative duration: 6-72 hours. If sending precut slides, do not oven bake. Transport tissue block or 5 unstained (3-5 micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800)522-2787.(Min: 4 slides).If sending precut slides, do not oven bake.

Storage/Transport Temperature

Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Paraffin block with no tumor tissue remaining. Specimens with fixation delayed for more than one hour. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Biopsies fixed for less than 6 hours and greater than 72 hours. Cytology specimens fixed in alcohol. Decalcified specimens.

Remarks

Document time from tissue acquisition to fixation and fixation duration on submitting requisition or enter at time of order. Include surgical pathology report.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval
Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
05/18/2020
X
N/A
CPT Codes

88360 x2

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Components
Component Test Code* Component Chart Name LOINC
0049200 Estrogen Receptor IP 40556-3
0049201 % of Nuclei Staining (ER) 14228-1
0049205 Progesterone Receptor IP 10480-2
0049206 % of Nuclei Staining (PR) 14230-7
0049217 Estrog/Progest Receptor Interpretation 19146-0
2003377 Estrogen Receptor Intensity
2003378 Progesterone Receptor Intensity
2011429 EstrogRecp IHC Internal Control Staining
2011430 ProgstRecp IHC Internal Control Staining
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ER and PR IHC
  • ER, PGR IHC
  • ER, PGR staining
  • ER/PgR
  • ERA & PRA
  • ERPR
  • Steroid Receptor Assay
Estrogen/Progesterone Receptor with Interpretation by Immunohistochemistry