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Estrogen/Progesterone Receptor with Interpretation by Immunohistochemistry
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Ordering Recommendation
Aid in the prediction of response to antiestrogen agents for patients with ductal carcinoma in situ (DCIS) and invasive cancers.
Mnemonic
Methodology
Immunohistochemistry
Performed
Mon-Fri
Reported
Within 4 days
New York DOH Approval Status
Specimen Required
Tumor tissue.
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue no later than 1 hour after removal from patient. Fixative duration: 6-72 hours. If sending precut slides, do not oven bake. Transport tissue block or 5 unstained (3-5 micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800)522-2787.(Min: 4 slides).If sending precut slides, do not oven bake.
Room temperature or refrigerated. Ship in cooled container during summer months.
Paraffin block with no tumor tissue remaining. Specimens with fixation delayed for more than one hour. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Biopsies fixed for less than 6 hours and greater than 72 hours. Cytology specimens fixed in alcohol. Decalcified specimens.
Document time from tissue acquisition to fixation and fixation duration on submitting requisition or enter at time of order. Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Reference Interval
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
88360 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0049200 | Estrogen Receptor IP | 40556-3 |
| 0049201 | % of Nuclei Staining (ER) | 14228-1 |
| 0049205 | Progesterone Receptor IP | 10480-2 |
| 0049206 | % of Nuclei Staining (PR) | 14230-7 |
| 0049217 | Estrog/Progest Receptor Interpretation | 48767-8 |
| 0049244 | Fixative Used | |
| 0049246 | Time from Bx to Fixative | |
| 0049247 | Duration of Fixation | |
| 2003377 | Estrogen Receptor Intensity | |
| 2003378 | Progesterone Receptor Intensity | |
| 2011429 | EstrogRecp IHC Internal Control Staining | |
| 2011430 | ProgstRecp IHC Internal Control Staining | |
| 3005643 | Sample Adequacy | |
| 3005650 | ERPR Reference Number | |
| 3005651 | ERPR Tissue Source |
Aliases
- ER and PR IHC
- ER, PGR IHC
- ER, PGR staining
- ER/PgR
- ERA & PRA
- ERPR
- Steroid Receptor Assay
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