Ordering Recommendation

Acceptable panel to detect protein C and S deficiencies. Preferred test for detecting protein S deficiency is Protein S Free, Antigen (0098894). Do not order if the individual has been on warfarin therapy in the previous 2-4 weeks.

Mnemonic
C/S PANEL
Methodology

Electromagnetic Mechanical Clot Detection

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Light Blue (Sodium Citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. EDTA plasma, clotted or hemolyzed specimens.

Remarks
Stability

Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months

Reference Interval
Test Number
Components
Reference Interval
0030113 Protein C, Functional Effective November 17, 2014
Age Reference Interval
1-4 days 17-53%
5-29 days 20-64%
30-89 days 21-65%
90-179 days 28-80%
180-364 days 37-81%
1-6 years 40-92%
7-9 years 70-142%
10-11 years 68-143%
12-13 years 66-162%
14-15 years 69-170%
16-17 years 70-171%
18 years and older 83-168%

0030114 Protein S, Functional Male
1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-5 years: 62-120%
6 years:  62-130%
7-9 years: 66-140%
10-11 years: 65-139%
12-13 years: 72-139%
14-15 years: 68-145%
16-17 years: 77-167%
18 years and older: 66-143%

Female

1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-5 years: 62-120%
6 years:  62-130%
7-9 years: 62-151%
10-11 years: 65-142%
12-13 years: 70-140%
14-15 years: 55-145%
16-17 years: 51-147%
18 years and older: 57-131%

Interpretive Data

Refer to report.

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

85303; 85306

Components
Component Test Code* Component Chart Name LOINC
0030113 Protein C Functional 27819-2
0030114 Protein S Functional 27822-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Protein C & S
  • Protein C and S Activity
Protein C and S Panel, Functional