Ordering Recommendation

Acceptable panel to detect protein C and S deficiencies. Preferred test for detecting protein S deficiency is Protein S Free, Antigen (0098894). Do not order if the individual has been on warfarin therapy in the previous 2-4 weeks.

Mnemonic

C/S PANEL

Methodology

Electromagnetic Mechanical Clot Detection

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Light Blue (Sodium Citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. EDTA plasma, clotted or hemolyzed specimens.

Remarks
Stability

Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months

Reference Interval

Test Number
Components
Reference Interval
  Protein C Functional
Age Reference Interval (%)
1-4 days 17-53
5-29 days 20-64
30-89 days 21-65
90-179 days 28-80
180-364 days 37-81
1-6 years 40-92
7-9 years 70-142
10-11 years 68-143
12-13 years 66-162
14-15 years 69-170
16-17 years 70-171
18 years and older 83-168

  Protein S Functional
Age Male (%) Female (%)
1-89 days 15-55 15-55
90-179 days 35-92 35-92
180-364 days 45-115 45-115
1-5 years 62-120 62-120
6 years 62-130 62-130
7-9 years 66-140 62-151
10-11 years 65-139 65-142
12-13 years 72-139 70-140
14-15 years 68-145 55-145
16-17 years 77-167 51-147
18 years and older 66-143 57-131

Interpretive Data

Refer to report.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

85303; 85306

Components

Component Test Code* Component Chart Name LOINC
0030113 Protein C Functional 27819-2
0030114 Protein S Functional 27822-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Protein C & S
  • Protein C and S Activity
Protein C and S Panel, Functional