Lupus Anticoagulant Reflexive Panel
Ordering Recommendation
Methodology
Electromagnetic Mechanical Clot Detection
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
Specimen Required
Light blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 2 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum. EDTA plasma, clotted or hemolyzed specimens.
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C or below: 3 months; Frozen at -70°C or below: 18 months
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
Dilute Russell Viper Venom Time (dRVVT) | 33-44 seconds | |
Dilute Russell Viper Venom (dRVVT) 1:1 Mix (performed if dRVVT > 44 seconds) | 33-44 seconds | |
Dilute Russell Viper Venom Time (dRVVT) Confirmation Test (performed if dRVVT 1:1 Mix > 44 seconds) | Negative | |
Prothrombin Time | 12.0-15.5 seconds | |
Partial Thromboplastin Time | 32-48 seconds | |
Thrombin Time | 14.7-19.5 seconds | |
Reptilase Time | Less than 22.0 seconds | |
PTT Heparin Neutralized | 32-48 seconds | |
Partial Thromboplastin Time 1:1 Mix (performed if PTT > 48 seconds) | 32-48 seconds | |
Platelet Neutralization Procedure (performed if PTT 1:1 Mix > 48 seconds) | Negative | |
Hexagonal Phospholipid Neutralization | Negative |
Interpretive Data
FDA
Note
If PTT and dRVVT are normal, then no further testing is performed. If PTT is abnormal, Thrombin Time is added. If Thrombin Time is normal, PTT 1:1 mix is added. If Thrombin time is abnormal, Reptilase Time and PTT Heparin Neutralization is added. If PTT Heparin Neutralization is abnormal, PTT 1:1 mix is added. If PTT 1:1 mix is abnormal, Platelet Neutralization procedure is added. If dRVVT is abnormal, dRVVT 1:1 mix is added. If dRVVT 1:1 mix is abnormal, dRVVT confirmation is added. If Platelet Neutralization procedure and dRVVT confirmation are normal or if one is normal and the other not done, Hexagonal Phospholipid Neutralization is added. Additional charges apply.
Hotline History
CPT Codes
85610; 85730; 85613; if reflexed, additional CPT codes may apply: 85670; 85635; 85730; 85525; 85732; 85597; 85613; 85598.
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0030079 | Lupus Anticoagulant Interpretation | 75882-1 |
0030082 | Hexagonal Phospholipid Neutral Reflex | 33930-9 |
0030084 | PTT-D Heparin Neutralized | 52123-7 |
0030184 | Platelet Neutralization (PTT-D, Confirm) | 75881-3 |
0030189 | dRVVT Confirmation | 50410-0 |
0030232 | PTT-LA Screen (PTT-D) | 34571-0 |
0030246 | Prothrombin Time | 5902-2 |
0030270 | Thrombin Time | 3243-3 |
0030296 | Reptilase Time | 6683-7 |
0030323 | PTT-D 1:1 Mix | 5946-9 |
0030352 | dRVVT Screen | 6303-2 |
0030353 | dRVVT 1:1 Mix | 75513-2 |
Aliases
- DRVVT
- dRVVT 1:1 Mix
- dRVVT Confirmation
- dRVVT Screen
- Hexagonal Phospholipid Neutral Reflex
- Lupus 1
- Lupus Anticoagulant
- Lupus Anticoagulant Comprehensive
- Lupus Anticoagulant with Reflex to Phospholipid Neutralization
- Lupus Inhibitor
- Platelet Neutralization
- Prothrombin Time
- PTT-D Heparin Neutralized
- PTT-LA Screen
- Reptilase Time
- Thrombin Time