Ordering Recommendation

Not recommended. Preferred tests for detection of protein C and S deficiencies are Protein C, Functional (0030113) and Protein S Free, Antigen (0098894). Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. EDTA plasma, clotted or hemolyzed specimens.


Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months


Enzyme-Linked Immunosorbent Assay (ELISA)/Microlatex Particle-Mediated Immunoassay




1-2 days

Reference Interval

Test Number
Reference Interval
  Protein C, Total Antigen
Age Reference Interval (%)
1-4 days 17-53
5-29 days 20-64
30-89 days 21-65
90-179 days 28-80
180-364 days 37-81
1-5 years 40-92
6-10 years 45-93
11 years and older 63-153

  Protein S, Total Antigen
Age Male (%) Female (%)
1-4 days 12-60 12-60
5-29 days 22-78 22-78
30-89 days 33-93 33-93
90-179 days 54-118 54-118
180-364 days 55-119 55-119
1-5 years 54-118 54-118
6-10 years 41-114 41-114
11 years and older 84-134 63-126

Interpretive Data

Refer to report.

Compliance Category



Hotline History


CPT Codes

85302; 85305


Component Test Code* Component Chart Name LOINC
0030111 Protein C, Total Antigen 27820-0
0030112 Protein S, Total Antigen 27823-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Protein C & S, Antigen
Protein C and S Panel, Total, Antigen