Ordering Recommendation

Not recommended. Preferred tests for detection of protein C and S deficiencies are Protein C, Functional (0030113) and Protein S Free, Antigen (0098894). Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.


Microlatex Particle-Mediated Immunoassay, Enzyme Immunoassay




1-2 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. EDTA plasma, clotted or hemolyzed specimens.


Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months

Reference Interval
Test Number
Reference Interval
0030111 Protein C, Total Antigen 1-4 days: 17-53%
5-29 days: 20-64%
30-89 days: 21-65%
90-179 days: 28-80%
180-364 days: 37-81%
1-5 years: 40-92%
6-10 years: 45-93%
11 years and older: 63-153%
0030112 Protein S, Total Antigen
Age Male Female
1-4 days 12-60% 12-60%
5-29 days 22-78% 22-78%
30-89 days 33-93% 33-93%
90-179 days 54-118% 54-118%
180-364 days 55-119% 55-119%
1-5 years 54-118% 54-118%
6-10 years 41-114% 41-114%
11 years and older 84-134% 63-126%

Interpretive Data

Refer to report.

No compliance statements are in use for this test.

Hotline History
CPT Codes

85302; 85305

Component Test Code* Component Chart Name LOINC
0030111 Protein C, Total Antigen 27820-0
0030112 Protein S, Total Antigen 27823-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Protein C & S, Antigen
Protein C and S Panel, Total, Antigen