Ordering Recommendation

Assist in diagnosing acquired (idiopathic) or inherited thrombotic thrombocytopenic purpura (TTP).

Mnemonic
ADAMTS-13
Methodology

Chromogenic Assay

Performed

Mon-Sun

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 1 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum, EDTA plasma, clotted or hemolyzed specimens.

Remarks
Stability

Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks

Reference Interval

Effective November 17, 2014

Greater than 60 percent

Interpretive Data

ADAMTS13 levels of less than 10 percent may be associated with either inherited (Upshaw-Schulman Syndrome) or acquired thrombotic thrombocytopenic purpura (TTP).

A variety of medical conditions may result in a mild to moderate deficiency of ADAMTS13 activity. Recent plasma exchange therapy may raise the observed ADAMTS13 activity.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

85397

Components
Component Test Code* Component Chart Name LOINC
0030049 ADAMTS13 Activity 53622-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • von Willebrand Factor Cleaving Protease
ADAMTS13 Activity