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Protein C, Functional with Reflex to Protein C, Total Antigen
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Ordering Recommendation
Acceptable test to detect and subtype protein C deficiency. Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.
Mnemonic
Methodology
Electromagnetic Mechanical Clot Detection/Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-5 days
New York DOH Approval Status
Specimen Required
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum. EDTA plasma, clotted or hemolyzed specimens.
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months
Reference Interval
By report
Interpretive Data
Patients on warfarin may have decreased protein C values. Patients should be off warfarin therapy for two weeks for accurate measurement of protein C levels. Artificially increased functional protein C values may be due to heparin therapy or the presence of direct thrombin inhibitors or factor Xa inhibitors.
FDA
Note
If Protein C functional is decreased, then Protein C, Total Antigen, will be added. Additional charges apply.
Hotline History
CPT Codes
85303; if reflexed, add 85302
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0030113 | Protein C Functional | 27819-2 |
Aliases
- Protein C Profile
- Protein C, functional and total
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