Ordering Recommendation

Acceptable test to detect and subtype protein C deficiency. Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.

Mnemonic
PROT CF R
Methodology

Electromagnetic Mechanical Clot Detection/Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. EDTA plasma, clotted or hemolyzed specimens.

Remarks
Stability

Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months

Reference Interval

By report

Interpretive Data

Patients on warfarin may have decreased protein C values. Patients should be off warfarin therapy for two weeks for accurate measurement of protein C levels. Artificially increased functional protein C values may be due to heparin therapy or the presence of direct thrombin inhibitors or factor Xa inhibitors.

Compliance Category

FDA

Note

If Protein C functional is decreased, then Protein C, Total Antigen, will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

85303; if reflexed, add 85302

Components
Component Test Code* Component Chart Name LOINC
0030113 Protein C Functional 27819-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Protein C Profile
  • Protein C, functional and total
Protein C, Functional with Reflex to Protein C, Total Antigen