Ordering Recommendation

Useful in the assessment of acute and chronic exposure to arsenic, cadmium, copper, mercury, lead, and zinc. The preferred test for the assessment of lead exposure is Lead, Blood (Venous) (0020098). For occupational exposure, consider Lead, Industrial Exposure Panel, Adults (0025016) and/or Cadmium Exposure Panel - OSHA (0025013).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, non-essential over-the-counter medications (upon the advice of their physician), and avoid shellfish and seafood for 48 to 72 hours. Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post-contrast media exposure.


24 Hour Urine. Refrigerate during collection. Specimen must be collected in a plastic container. Also acceptable: Random Urine.

Specimen Preparation

Transfer 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 2 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Unacceptable Conditions

Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material.


Trace Elements requisition form may be required (ARUP form #32990-Barcode; #32991-No Barcode). Record total volume and collection time interval on transport tube and on test request form.


Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year


Quantitative Inductively Coupled Plasma-Mass Spectrometry




1-5 days

Reference Interval

Test Number
Reference Interval
  Copper, Urine - per volume Less than or equal to 3.2 µg/dL
  Copper, Urine - per 24h 3.0-45.0 µg/d
  Zinc, Urine - per volume 15.0-120.0 µg/dL
  Zinc, Urine - per 24h 150.0-1200.0 µg/d
  Creatinine, Urine - per 24h
Male (mg/d)
Female (mg/d)
3-8 years 140-700 140-700
9-12 years 300-1300 300-1300
13-17 years 500-2300 400-1600
18-50 years 1000-2500 700-1600
51-80 years 800-2100 500-1400
81 years and older 600-2000 400-1300

  Arsenic Urine - per volume 0.0-34.9 µg/L
  Arsenic Urine - per 24h 0.0-49.9 µg/d
  Cadmium, Urine - ratio to CRT 0.0-3.2 µg/g CRT
  Cadmium, Urine - per 24h 0.0-3.2 µg/d
  Cadmium, Urine - per volume 0.0-1.0 µg/L
  Mercury, Urine - per 24h 0.0-20.0 µg/d
  Mercury, Urine - per volume 0.0-5.0 µg/L
  Mercury, Urine - ratio to CRT 0.0-20.0 µg/g CRT
  Arsenic, Urine - ratio to CRT 0.0-29.9 µg/g CRT
  Lead, Urine - per 24h 0.0-8.1 µg/d
  Lead, Urine - per volume 0.0-5.0 µg/L
  Zinc, Urine - ratio to CRT 110.0-750.0 µg/g CRT
  Copper, Urine - ratio to CRT 10.0-45.0 µg/g CRT
  Lead, Urine - ratio to CRT 0.0-5.0 µg/g CRT

Interpretive Data

Refer to report

Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


High concentrations of iodine or gadolinium may interfere with elemental testing.  If total arsenic concentration is found to be elevated based on reference intervals, then Arsenic, Fractionated, will be added to determine the proportion of organic, inorganic, and methylated forms. Additional charges apply.

Hotline History


CPT Codes

82175; 82300; 82525; 83655; 83825; 84630; if reflexed, add 82175


Component Test Code* Component Chart Name LOINC
0020100 Copper, Urine - per volume 5632-5
0020101 Copper, Urine - per 24h 5633-3
0020102 Zinc, Urine - per volume 21610-1
0020103 Zinc, Urine - per 24h 5765-3
0020207 Creatinine, Urine - per volume 2161-8
0020208 Creatinine, Urine - per 24h 2162-6
0025001 Arsenic Urine - per volume 5586-3
0025002 Arsenic Urine - per 24h 5587-1
0025038 Cadmium, Urine - ratio to CRT 13828-9
0025041 Cadmium, Urine - per 24h 5612-7
0025042 Cadmium, Urine - per volume 5611-9
0025051 Mercury, Urine - per 24h 6693-6
0025052 Mercury, Urine - per volume 5689-5
0025054 Mercury, Urine - ratio to CRT 13465-0
0025058 Arsenic, Urine - ratio to CRT 13463-5
0025061 Lead, Urine - per 24h 5677-0
0025062 Lead, Urine - per volume 5676-2
0025063 Zinc, Urine - ratio to CRT 27201-3
0025064 Copper, Urine - ratio to CRT 13829-7
0025065 Lead, Urine - ratio to CRT 13466-8
0097110 Total Volume 19153-6
0097111 Hours Collected 30211-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Arsenic
  • As fractionation
  • Cadmium
  • Cd
  • Copper
  • Cu
  • heavy metals urine screen
  • Hg
  • Inorganic As
  • Lead
  • Mercury
  • methylated As
  • Organic As
  • Pb
  • Zinc
  • Zn
Heavy Metals Panel 6, Urine with Reflex to Arsenic Fractionated