Cobalt, Serum or Plasma
May be used in the assessment of occupational exposure or toxic ingestion.
Quantitative Inductively Coupled Plasma-Mass Spectrometry
New York DOH Approval Status
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).
Royal Blue (No Additive) or Royal Blue (K2 EDTA), or Royal Blue (Na2 EDTA).
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)
Room temperature. Also acceptable: Refrigerated or frozen.
Specimens collected in containers other than specified. Specimens transported in containers other than specified.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely
Less than or equal to 1.0 µg/L
Elevated results may be due to skin or collection-related contamination, including the use of a noncertified metal-free collection/transport tube. If contamination concerns exist due to elevated levels of serum/plasma cobalt, confirmation with a second specimen collected in a certified metal-free tube is recommended.
Serum cobalt levels can be used in the assessment of occupational exposure or toxic ingestion. Symptoms associated with cobalt toxicity vary based on route of exposure, and may include cardiomyopathy, allergic dermatitis, pulmonary fibrosis, cough, and dyspnea.
Serum cobalt levels can be significantly higher in patients with metal-on-metal total hip replacement implants than in control patients without metal implants. Serum cobalt levels may be increased in asymptomatic patients with metal-on-metal prosthetics and should be considered in the context of the overall clinical scenario. Whole blood is the specimen type recommended by the U.S. Food and Drug Administration for assessing the risks of metal-on-metal hip implants in symptomatic patients.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0025037||Cobalt, Serum or Plasma||5627-5|
- Plasma cobalt level