0025000
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  Arsenic, Urine with Reflex to Fractionated

ARS U
Example Reports
Not Reflexed
Reflexed

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Public Health Demographics Form: submit ONLY if complete demographic info is not transmitted to ARUP

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Specimen Collection and Handling

Ordering Recommendation

Preferred test for the assessment of acute or chronic arsenic exposure. This test is able to differentiate between toxic inorganic and methylated species as well as benign organic forms. Results are reported as total inorganic, total methylated, and organic arsenic

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, nonessential over-the-counter medications (upon the advice of their physician), and avoid shellfish and seafood for 48 to 72 hours. High concentrations of iodine may interfere with elemental testing. Collection of urine specimens from patients receiving iodinated or gadolinium-based contrast media should be avoided for a minimum of 72 hours post exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.

Collect

24-hour or random urine collection. Specimen must be collected in a plastic container and refrigerated during collection. ARUP studies indicate that refrigeration of urine alone, during and after collection, preserves specimens adequately if tested within 14 days of collection.

Specimen Preparation

Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116) available online through eSupply using ARUP Connect(TM) or contact ARUP Client Services at 800-522-2787. (Min: 2 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Unacceptable Conditions

Acid preserved urine. Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Specimens contaminated with blood or fecal material. Specimens transported in nontrace element-free transport tube (with the exception of the original device).

Remarks

Record total volume and collection time interval on transport tube and on test request form.

Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 2 months

Methodology

Quantitative High Performance Liquid Chromatography (HPLC) / Quantitative Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Performed

Sun-Sat

Reported

1-5 days

Reference Interval

Test Number
 Components
 Reference Interval
  Creatinine, Urine - per 24h
Age
 Male (mg/d)
 Female (mg/d)
3-8 years 140-700 140-700
9-12 years 300-1300 300-1300
13-17 years 500-2300 400-1600
18-50 years 1000-2500 700-1600
51-80 years 800-2100 500-1400
81 years and older 600-2000 400-1300

  Arsenic Urine - per volume Less than or equal to 34.9 microg/L
  Arsenic Urine - per 24h Less than or equal to 49.9 microg/d
  Arsenic, Urine - ratio to CRT Less than or equal to 29.9 microg/g CRT

Interpretive Data

The ACGIH Biological Exposure Index (BEI) for arsenic in urine is 35 ug/L measured at the end of the work week. The ACGIH BEI is based on the sum of inorganic and methylated species. For specimens with elevated total arsenic results, fractionation is automatically performed to determine the proportions of inorganic, methylated, and organic species.
Elevated results may be due to skin or collection-related contamination, including the use of collection containers that are not certified to be trace element-free. If an elevated result is suspected to be due to contamination, confirmation with a second specimen collected in a certified trace element-free container is recommended.
Methodology: Inductively Coupled Plasma - Mass Spectrometry (ICP-MS)

Compliance Category

Laboratory Developed Test (LDT)

Note

If total arsenic concentration is found to be elevated based on reference intervals, then Arsenic, Fractionated, will be added to determine the proportion of organic, inorganic, and methylated forms. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
01/20/2026
X
X
X
N/A

CPT Codes

82175; if reflexed, add 82175

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Components

Component Test Code* Component Chart Name LOINC
0020207 Creatinine, Urine - per volume 35674-1
0020208 Creatinine, Urine - per 24h 2162-6
0025001 Arsenic Urine - per volume 30924-5
0025002 Arsenic Urine - per 24h 5587-1
0025058 Arsenic, Urine - ratio to CRT 13463-5
0097110 Total Volume 19153-6
0097111 Hours Collected 30211-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Arsenic/Creatinine Ratio, Random, Urine
  • As
  • ASU
  • Normalized Urine As, Normalized Urine Arsenic
Arsenic, Urine with Reflex to Fractionated