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Alkaline Phosphatase Isoenzymes, Serum or Plasma
Ordering Recommendation
Use when total alkaline phosphatase activity is elevated to determine amounts contributed by bone and liver isoenzymes.
New York DOH Approval Status
Specimen Required
Serum separator tube (SST) or green (sodium or lithium heparin).
Allow serum specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP standard transport tube and refrigerate or freeze immediately. (Min: 1 mL)
Refrigerated
Specimens collected in EDTA, sodium fluoride, sodium citrate, or potassium oxalate. Grossly hemolyzed or lipemic specimens.
After separation from cells: Room Temperature: 1 week; Refrigerated: 1 week; Frozen: 2 months
Methodology
Quantitative Heat Inactivation/Enzymatic Assay
Performed
Sun-Sat
Reported
1-4 days
Reference Interval
| Test Number |
Components |
||
|---|---|---|---|
| 0020005 | Alkaline Phosphatase, Serum or Plasma | Male 0-30 days: 60-320 U/L 1-11 months: 70-350 U/L 1-3 years: 125-320 U/L 4-6 years: 150-370 U/L 7-9 years: 150-440 U/L 10-11 years: 150-470 U/L 12-13 years: 160-500 U/L 14-15 years: 130-530 U/L 16-19 years: 60-270 U/L 20 years and older: 40-120 U/L |
Female 0-30 days: 60-320 U/L 1-11 months: 70-350 U/L 1-3 years: 125-320 U/L 4-6 years: 150-370 U/L 7-9 years: 150-440 U/L 10-11 years: 150-530 U/L 12-13 years: 110-525 U/L 14-15 years: 55-305 U/L 16-19 years: 40-120 U/L 20 years and older: 40-120 U/L |
| Bone | Male 1-6 years: 0-208 U/L 7-9 years: 0-264 U/L 10-15 years: 0-340 U/L 16-19 years: 0-165 U/L 20 years and older: 0-55 U/L |
Female 1-6 years: 0-189 U/L 7-9 years: 0-246 U/L 10-13 years: 0-340 U/L 14-15 years: 0-91 U/L 16 years and older: 0-55 U/L |
|
| Liver | Male 1-6 years: 0-145 U/L 7-11 years: 0-182 U/L 12-15 years: 0-226 U/L 16-19 years: 0-114 U/L 20 years and older: 0-94 U/L |
Female 1-9 years: 0-148 U/L 10-15 years: 0-162 U/L 16 years and older: 0-94 U/L |
Interpretive Data
Bone Specific Alkaline Phosphatase (0070053) and 5'Nucleotidase (0080235) may be useful in identifying disorders of bone and liver, respectively.
Laboratory Developed Test (LDT)
Note
The presence of heat-stable isoenzymes (i.e., germ cell and placental) will be detected but their activities cannot be differentiated from the liver isoenzyme.
Hotline History
CPT Codes
84075; 84080
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0020005 | Alkaline Phosphatase | 6768-6 |
| 0021006 | Alk-Phosphatase Other Calc | 33421-9 |
| 0021011 | Alk-Phosphatase Bone Calc | 1777-2 |
| 0021016 | Alk-Phosphatase Liver Calc | 1779-8 |
Aliases
- ALK PHOS
- Alkaline Phosphatase
- Alkaline Phosphatase Isoenzymes by Heat Fractionation
- Alkp
