Ordering Recommendation

May be useful when related serum or urine assessments are inconclusive.

Mnemonic
CU-LIVER
Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry

Performed

Mon, Wed, Thu, Fri, Sat

Reported

2-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Liver tissue obtained with an 18 gauge needle.

Specimen Preparation

Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container such as a royal blue (no additive).

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Specimens less than 0.25 mg (dry weight). Paraffin blocks that have been processed with Hollandes or other copper-containing stain.

Remarks
Stability

Paraffin block, preserved (formalin), or dried: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely
Fresh tissue: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Indefinitely

Reference Interval

15-55 µg/g of tissue.

Interpretive Data

Hepatic copper concentrations approach or exceed 250 µg/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions. Results inconsistent with other findings may reflect heterogeneity in hepatic copper distribution.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
CPT Codes

82525

Components
Component Test Code* Component Chart Name LOINC
0020695 Tissue Weight 29638-4
0020697 Hepatic Copper Concentration by Weight 56126-6
2004962 EER Copper, Liver 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Copper Tissue
  • Cu
  • Hepatic Copper Concentration
  • Metals, Tissue
  • Quantitative Copper, Tissue
Copper, Liver