May be useful when related serum or urine assessments are inconclusive.
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Mon, Wed, Thu, Fri, Sat
Liver tissue obtained with an 18 gauge needle.
Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container such as a royal blue (no additive).
Specimens less than 0.25 mg (dry weight). Paraffin blocks that have been processed with Hollandes or other copper-containing stain.
Paraffin block, preserved (formalin), or dried: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely
Fresh tissue: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Indefinitely
15-55 µg/g of tissue.
Hepatic copper concentrations approach or exceed 250 µg/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions. Results inconsistent with other findings may reflect heterogeneity in hepatic copper distribution.
Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
|Component Test Code*||Component Chart Name||LOINC|
|0020697||Hepatic Copper Concentration by Weight||56126-6|
|2004962||EER Copper, Liver||11526-1|
- Copper Tissue
- Hepatic Copper Concentration
- Metals, Tissue
- Quantitative Copper, Tissue