May be useful when related serum or urine assessments are inconclusive.
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Mon, Wed, Thu, Fri, Sat
Liver tissue obtained with an 18 gauge needle.
Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container such as a royal blue (no additive).
Specimens less than 0.25 mg (dry weight). Paraffin blocks that have been processed with Hollandes or other copper-containing stain.
Paraffin block, preserved (formalin), or dried: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely
Fresh tissue: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Indefinitely
15-55 µg/g of tissue.
Hepatic copper concentrations approach or exceed 250 µg/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions. Results inconsistent with other findings may reflect heterogeneity in hepatic copper distribution.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0020697||Hepatic Copper Concentration by Weight||56126-6|
|2004962||EER Copper, Liver||11526-1|
- Copper Tissue
- Hepatic Copper Concentration
- Metals, Tissue
- Quantitative Copper, Tissue