Ordering Recommendation

Use as an OSHA-mandated indicator to assess lead exposure in the industrial setting. For a complete assessment of industrial lead exposure in adults and exposure guidance in accordance with OSHA regulations, Lead, Industrial Exposure Panel, Adults (0025016) can be ordered.


Quantitative Hematofluorometry




1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Lavender (EDTA), royal blue (EDTA), or tan (EDTA). Use royal blue (EDTA) tube when also testing for lead.

Specimen Preparation

Transport 1 mL whole blood. (Min: 0.2 mL)

Storage/Transport Temperature


Unacceptable Conditions

Specimens not collected in EDTA. Clotted, frozen, or hemolyzed specimens.


Ambient: 30 hours; Refrigerated: 5 weeks; Frozen: Unacceptable

Reference Interval

Test Number
Reference Interval
  Zinc Protoporphyrin, Blood 0-40 µg/dL
  Zinc Protoporphyrin (ZPP) WholeBld Ratio 0-69 µmol ZPP/mol heme

Interpretive Data

For occupational exposure to lead, OSHA requires ZPP whole blood concentration to be reported in units of µg/dL. For adults, conversion of ZPP to units of µg/dL assumes a hematocrit of 45%. This test was performed on the ProtoFluor Z system manufactured by Helena Laboratories. The result is not comparable to results obtained from extraction-based methods or from the AVIV ZPP system.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes. 

Compliance Category

Laboratory Developed Test (LDT)


Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria.  Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0020606 Zinc Protoporphyrin (ZPP) WholeBld Ratio 29763-0
0020613 Zinc Protoporphyrin, Blood 2895-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • ZP
  • Porphyrins
  • ZPP
  • ZPP/Heme Ratio
Zinc Protoporphyrin (ZPP), Whole Blood Industrial