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Zinc Protoporphyrin (ZPP), Whole Blood Industrial
Ordering Recommendation
Use as an OSHA-mandated indicator to assess lead exposure in the industrial setting. For a complete assessment of industrial lead exposure in adults and exposure guidance in accordance with OSHA regulations, Lead, Industrial Exposure Panel, Adults (0025016) can be ordered.
New York DOH Approval Status
Specimen Required
Lavender (EDTA), royal blue (K2EDTA), royal blue (NaHep), tan (K2EDTA) or pink (K2EDTA).
Transport 3 or 6 mL whole blood in the original collection tube. (Min: 0.2 mL)
Refrigerated.
Clotted, frozen, or hemolyzed specimens.
Ambient: 30 hours; Refrigerated: 5 weeks; Frozen: Unacceptable
Methodology
Quantitative Hematofluorometry
Performed
Mon-Fri
Reported
1-4 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Zinc Protoporphyrin, Blood | 0-40 µg/dL | |
| Zinc Protoporphyrin (ZPP) WholeBld Ratio | 0-69 µmol ZPP/mol heme |
Interpretive Data
For occupational exposure to lead, OSHA requires ZPP whole blood concentration to be reported in units of ug/dL. For adults, conversion of ZPP to units of ug/dL assumes a hematocrit of 45%. This test was performed on the ProtoFluor Z system manufactured by Helena Laboratories. The result is not comparable to results obtained from extraction-based methods or from the AVIV ZPP system.
Laboratory Developed Test (LDT)
Note
Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria. Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.
Hotline History
CPT Codes
84202
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0020606 | Zinc Protoporphyrin (ZPP) WholeBld Ratio | 29763-0 |
| 0020613 | Zinc Protoporphyrin, Blood | 2895-1 |
Aliases
- ZP
- Porphyrins
- ZPP
- ZPP/Heme Ratio
