Zinc Protoporphyrin (ZPP), Whole Blood
This test should not be used as the primary screening test for lead exposure; the preferred test for lead exposure assessment is Lead Blood (Venous) (0020098). For iron deficiency assessment, Iron and Iron Binding Capacity (0020420) and Ferritin (0070065) are recommended. For assessment of occupational exposure to lead, Lead Industrial Exposure Panel, Adults (0025016) is recommended.
New York DOH Approval Status
Lavender (EDTA); Royal blue, (EDTA), tan (EDTA), or pink (K2 EDTA). Use royal blue (EDTA) tube when also testing for lead.
Transport 1 mL whole blood. (Min: 0.2 mL)
Specimens not collected in EDTA. Clotted, frozen, or hemolyzed specimens.
Ambient: 30 hours; Refrigerated: 5 weeks; Frozen: Unacceptable
0-69 µmol ZPP/ mol Hem
This test was performed on the ProtoFluor Z system manufactured by Helena Laboratories. The result is not comparable to results obtained from extraction-based methods or from the AVIV ZPP system.
The test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria. Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.
A more specific test for free protoporphyrin is Porphyrins, Serum Total (0080429). Erythrocyte Porphyrin (EP), Whole Blood (0020610), measures free protoporphyrin and zinc protoporphyrin.
|Component Test Code*||Component Chart Name||LOINC|
|0020606||Zinc Protoporphyrin (ZPP) WholeBld Ratio||29763-0|
- ZPP/Heme Ratio