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Zinc Protoporphyrin (ZPP), Whole Blood
Ordering Recommendation
This test should not be used as the primary screening test for lead exposure; the preferred test for lead exposure assessment is Lead Blood (Venous) (0020098). For iron deficiency assessment, Iron and Iron Binding Capacity (0020420) and Ferritin (0070065) are recommended. For assessment of occupational exposure to lead, Lead Industrial Exposure Panel, Adults (0025016) is recommended.
New York DOH Approval Status
Specimen Required
Lavender (EDTA), royal blue (K2EDTA), royal blue (NaHep),tan (K2EDTA), or pink (K2EDTA).
Transport 3 or 6 mL whole blood in the original collection tube. (Min: 0.2 mL)
Refrigerated.
Clotted, frozen, or hemolyzed specimens.
Ambient: 30 hours; Refrigerated: 5 weeks; Frozen: Unacceptable
Methodology
Quantitative Hematofluorometry
Performed
Mon-Fri
Reported
1-4 days
Reference Interval
0-69 µmol ZPP/ mol Hem
Interpretive Data
This test was performed on the ProtoFluor Z system manufactured by Helena Laboratories. The result is not comparable to results obtained from extraction-based methods or from the AVIV ZPP system.
Laboratory Developed Test (LDT)
Note
Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria. Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.
A more specific test for free protoporphyrin is Porphyrins, Serum Total (0080429). Erythrocyte Porphyrin (EP), Whole Blood (0020610), measures free protoporphyrin and zinc protoporphyrin.
Hotline History
CPT Codes
84202
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0020606 | Zinc Protoporphyrin (ZPP) WholeBld Ratio | 29763-0 |
Aliases
- Porphyrins
- ZP
- ZPP
- ZPP/Heme Ratio
