Ordering RecommendationRecommendations when to order or not order the test. May include related or preferred tests.
Useful as an indicator of chronic exposure to lead, primarily in the industrial setting. For iron deficiency assessment, Iron and Iron Binding Capacity (0020420) and Ferritin (0070065) are recommended. For lead exposure assessment, Lead Blood (Venous) (0020098) is preferred. For occupational exposure to lead assessment, Zinc Protoporphyrin (ZPP) Whole Blood Industrial (0020614) or Lead Industrial Exposure Panel, Adults (0025016) are recommended.
MnemonicUnique test identifier.
ZPP
MethodologyProcess(es) used to perform the test.
Quantitative Hematofluorometry
PerformedDays of the week the test is performed.
Mon-Fri
ReportedExpected turnaround time for a result, beginning when ARUP has received the specimen.
1-4 days
New York DOH Approval StatusIndicates test has been approved by the New York State Department of Health.
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect
Lavender (EDTA); Royal blue, (EDTA), tan (EDTA), or pink (K2 EDTA). Use royal blue (EDTA) tube when also testing for lead.
Specimen Preparation
Transport 1 mL whole blood. (Min: 0.2 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Specimens not collected in EDTA. Clotted, frozen, or hemolyzed specimens.
Reference IntervalNormal range/expected value(s) for a specific disease state. May also include abnormal ranges.
0-69 µmol ZPP/ mol Hem
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Compliance Category
Laboratory Developed Test (LDT)
NoteAdditional information related to the test.
Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria. Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.
A more specific test for free protoporphyrin is Porphyrins, Serum Total (0080429). Erythrocyte Porphyrin (EP), Whole Blood (0020610), measures free protoporphyrin and zinc protoporphyrin.
Hotline History
N/A
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
AliasesOther names that describe the test. Synonyms.
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