Ordering Recommendation

This test should not be used as the primary screening test for lead exposure; the preferred test for lead exposure assessment is Lead Blood (Venous) (0020098). For iron deficiency assessment, Iron and Iron Binding Capacity (0020420) and Ferritin (0070065) are recommended. For assessment of occupational exposure to lead, Lead Industrial Exposure Panel, Adults (0025016) is recommended.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Lavender (EDTA), Royal blue (K2EDTA), Royal blue (NaHep),tan (K2EDTA), or pink (K2EDTA).

Specimen Preparation

Transport 1 mL whole blood. (Min: 0.2 mL)

Storage/Transport Temperature


Unacceptable Conditions

Clotted, frozen, or hemolyzed specimens.


Ambient: 30 hours; Refrigerated: 5 weeks; Frozen: Unacceptable


Quantitative Hematofluorometry




1-4 days

Reference Interval

0-69 µmol ZPP/ mol Hem

Interpretive Data

This test was performed on the ProtoFluor Z system manufactured by Helena Laboratories. The result is not comparable to results obtained from extraction-based methods or from the AVIV ZPP system.

The test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria. Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.

A more specific test for free protoporphyrin is Porphyrins, Serum Total (0080429). Erythrocyte Porphyrin (EP), Whole Blood (0020610), measures free protoporphyrin and zinc protoporphyrin.

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0020606 Zinc Protoporphyrin (ZPP) WholeBld Ratio 29763-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Porphyrins
  • ZP
  • ZPP
  • ZPP/Heme Ratio
Zinc Protoporphyrin (ZPP), Whole Blood