Zinc Protoporphyrin (ZPP), Whole Blood

0020605
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Specimen Collection and Handling

Ordering Recommendation

May be useful as an indicator of lead exposure; not recommended as the primary screening test for lead exposure. For lead exposure assessment, Lead Blood (Venous) (0020098) is preferred. For iron deficiency assessment, Iron and Iron Binding Capacity (0020420) and Ferritin (0070065) are recommended. For assessment of occupational exposure to lead, Lead Industrial Exposure Panel, Adults (0025016) is recommended.

Mnemonic

ZPP

Methodology

Quantitative Hematofluorometry

Performed

Mon-Fri

Reported

1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA); Royal blue, (EDTA), tan (EDTA), or pink (K2 EDTA). Use royal blue (EDTA) tube when also testing for lead.

Specimen Preparation

Transport 1 mL whole blood. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Specimens not collected in EDTA. Clotted, frozen, or hemolyzed specimens.

Remarks
Stability

Ambient: 30 hours; Refrigerated: 5 weeks; Frozen: Unacceptable

Reference Interval

0-69 µmol ZPP/ mol Hem

Interpretive Data

This test was performed on the ProtoFluor Z system manufactured by Helena Laboratories. The result is not comparable to results obtained from extraction-based methods or from the AVIV ZPP system.

The test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria. Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.


A more specific test for free protoporphyrin is Porphyrins, Serum Total (0080429). Erythrocyte Porphyrin (EP), Whole Blood (0020610), measures free protoporphyrin and zinc protoporphyrin.

Hotline History

N/A

CPT Codes

84202

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Components

Component Test Code* Component Chart Name LOINC
0020606 Zinc Protoporphyrin (ZPP) WholeBld Ratio 29763-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Porphyrins
  • ZP
  • ZPP
  • ZPP/Heme Ratio
Zinc Protoporphyrin (ZPP), Whole Blood