Useful in the assessment of overload.
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.
24 Hour Urine. Refrigerate during collection. Specimen must be collected in a plastic container. Also acceptable: Random Urine.
Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL)
Refrigerated. Also acceptable: Room temperature or frozen.
Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media.. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material.
Record total volume and collection time interval on transport tube and on test request form.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year
Effective February 16, 2021
|Copper, Urine-per volume||Less than or equal to 3.2 µg/dL|
|Copper, Urine-per 24h||3.0-45.0 µg/d|
|Creatinine, Urine - per 24h||
|Copper, Urine-ratio to CRT||10.0-45.0 µg/gCRT|
Individuals with symptomatic Wilson disease usually excrete more than 100 µg copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.
Although random specimens may contain diagnostic information, a 24-hour collection is a more consistent indicator of copper urine.
Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Refer to Copper-Ceruloplasmin Index (Copper Free) (0025079) for Wilson disease screening test. High concentrations of iodine may interfere with elemental testing.
|Component Test Code*||Component Chart Name||LOINC|
|0020100||Copper, Urine - per volume||5632-5|
|0020101||Copper, Urine - per 24h||5633-3|
|0020207||Creatinine, Urine - per volume||2161-8|
|0020208||Creatinine, Urine - per 24h||2162-6|
|0025064||Copper, Urine - ratio to CRT||13829-7|
- 24-hour urine copper
- Copper/Creatinine Ratio, Urine
- Normalized Urine Copper
- Normalized Urine Cu